PMID- 1878843
OWN - NLM
STAT- MEDLINE
DCOM- 19910927
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 68
IP  - 6 Suppl
DP  - 1991 Sep 15
TI  - Use of intravenous immunoglobulin in acquired immune deficiency syndrome.
PG  - 1440-50
AB  - Patients infected with the human immunodeficiency virus (HIV) may have an 
      antibody deficiency and a deficiency of cellular immunity. Intravenous 
      immunoglobulin (IVIG) preparations may benefit HIV-infected children and adults 
      with recurrent bacterial infections at doses of 200 to 400 mg/kg every 2 to 4 
      weeks. In addition, IVIG (1 to 2 g/kg) is effective at raising platelet counts to 
      hemostatic levels in HIV-infected patients with idiopathic thrombocytopenic 
      purpura and life-threatening bleeding. Indirect evidence also suggests that IVIG 
      may be effective in preventing Pneumocystis carinii pneumonia. Finally, recent 
      studies suggest that specific anti-HIV antibody preparations may have a 
      therapeutic role, either as immunoglobulin concentrates or as immunoadhesions and 
      immunotoxins. However, further investigations are needed to exclude antibody 
      enhancement of HIV infection by the Fc receptor or the complement receptor.
FAU - Yap, P L
AU  - Yap PL
AD  - Edinburgh Blood Transfusion Service, Scotland, United Kingdom.
FAU - Todd, A A
AU  - Todd AA
FAU - Williams, P E
AU  - Williams PE
FAU - Hague, R A
AU  - Hague RA
FAU - Mok, J
AU  - Mok J
FAU - Burns, S M
AU  - Burns SM
FAU - Brettle, R P
AU  - Brettle RP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/complications/*therapy
MH  - Adult
MH  - Child
MH  - Humans
MH  - *Immunization, Passive
MH  - Infusions, Intravenous
MH  - Pneumonia, Pneumocystis/etiology/prevention & control
MH  - Purpura, Thrombocytopenic/etiology/prevention & control
RF  - 85
EDAT- 1991/09/15 00:00
MHDA- 1991/09/15 00:01
CRDT- 1991/09/15 00:00
PHST- 1991/09/15 00:00 [pubmed]
PHST- 1991/09/15 00:01 [medline]
PHST- 1991/09/15 00:00 [entrez]
AID - 10.1002/1097-0142(19910915)68:6+<1440::aid-cncr2820681407>3.0.co;2-y [doi]
PST - ppublish
SO  - Cancer. 1991 Sep 15;68(6 Suppl):1440-50. doi: 
      10.1002/1097-0142(19910915)68:6+<1440::aid-cncr2820681407>3.0.co;2-y.