PMID- 18788592
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20160818
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 37
IP  - 3
DP  - 2008 Mar
TI  - [Expression of cyclin G1 in laryngeal squamous cell carcinoma and its 
      clinicopathologic significance].
PG  - 165-8
AB  - OBJECTIVE: To evaluate the expression of cyclin G1 and its relationship with 
      clinical pathological characters, p53 expression and microvessel density (MVD) in 
      laryngeal squamous cell carcinoma (LSCC), and to investigate the prognostic value 
      of cyclin G1 in LSCC. METHODS: Using immunohistochemistry, 81 cases of LSCC were 
      evaluated for cyclin G1 and p52 expression, MVD was assessed by CD34 staining. In 
      20 cases, similar assessment was made in the adjacent normal mucosa. RESULTS: 
      Compared to the normal laryngeal mucosa, the expressions of cyclin Gl, p53 and 
      MVD were higher in LSCC than that in normal tissues. The positive rates of cyclin 
      G1 and p53 expressions in LSCC were 61.7% (50/81) and 65.4% (53/81), 
      respectively. The positive rates of cyclin G1 in LSCC with or without p53 
      expression were 71.7% (38/53) and 42.9% (12/28), respectively. The expression of 
      cyclin G1 was significantly correlated with p53 (P = 0.011). The mean value of 
      MVD was (51.23 +/- 16.46 mv) in cyclin G1 positive group, and(30.74 +/- 12.29 mv) 
      in the negative group, and the difference was significant (P = 0.005). 
      Furthermore, the over-expression of cyclin G1 was related to the histological 
      grade, cervical lymph node metastases and 5 year survival (P = 0.002, 0.013 and 
      0.032 respectively). CONCLUSIONS: Cyclin G1 is highly expressed in laryngeal 
      squamous cell carcinoma, and is associated with the expression of p53 protein and 
      tumor angiogenesis. It may play an important role in carcinogenesis and 
      metastasis in LSCC, and may be one of prognostic indices for LSCC patients.
FAU - Cui, Xiao-Feng
AU  - Cui XF
AD  - Department of Pathogenic Biology, College of Public Health and Tropical Disease, 
      Southern Medical University, Guangzhou 510515, China.
FAU - Liu, Ai-Jun
AU  - Liu AJ
FAU - Wei, Li-Xin
AU  - Wei LX
FAU - Chen, Xiao-Guang
AU  - Chen XG
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cyclin G1)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Squamous Cell/*diagnosis/metabolism
MH  - Cyclin G1/genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism
MH  - Lymph Nodes/*metabolism
MH  - Lymphatic Metastasis/*diagnosis
MH  - Prognosis
MH  - Proliferating Cell Nuclear Antigen/analysis
EDAT- 2008/09/16 09:00
MHDA- 2010/09/23 06:00
CRDT- 2008/09/16 09:00
PHST- 2008/09/16 09:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
PHST- 2008/09/16 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2008 Mar;37(3):165-8.