PMID- 18789598 OWN - NLM STAT- MEDLINE DCOM- 20090225 LR - 20081125 IS - 0306-9877 (Print) IS - 0306-9877 (Linking) VI - 72 IP - 1 DP - 2009 Jan TI - High-dose total body irradiation and bone marrow cells may improve efficiency of bone marrow transplantation therapy in treating type 1 diabetes. PG - 36-8 LID - 10.1016/j.mehy.2008.07.049 [doi] AB - Bone marrow transplantation (BMT) has been used to treat autoimmune diseases for many years. Insulin-dependent diabetes mellitus (IDDM), also called type 1 diabetes mellitus (T1DM), is a T cell-mediated autoimmune disease resulting from a selective destruction of pancreatic islet beta cells. Recently, T1D has been a common significant cause of morbidity and mortality. However, whether BMT can be used to treat T1DM is still controversial. During BMT procedure, recipients underwent total body irradiation (TBI) and subsequent bone marrow cells (BMCs) infusion, in which TBI kills off the most T lymphocytes and BMCs stimulates hematopoiesis and immune reconstitution. We suggest that high-dose TBI and BMCs may improve efficiency of BMT therapy in T1DM treatment. FAU - Wang, Jing AU - Wang J AD - Department of Hematology, DrumTower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, PR China. FAU - Yuan, Yang AU - Yuan Y FAU - Wen, Yanting AU - Wen Y FAU - Ouyang, Jian AU - Ouyang J LA - eng PT - Journal Article DEP - 20080911 PL - United States TA - Med Hypotheses JT - Medical hypotheses JID - 7505668 RN - 0 (Blood Glucose) SB - IM MH - Blood Glucose/metabolism MH - Bone Marrow Cells/physiology MH - Bone Marrow Transplantation/*methods MH - Combined Modality Therapy MH - Diabetes Mellitus, Type 1/blood/*radiotherapy/*surgery MH - Humans MH - *Whole-Body Irradiation EDAT- 2008/09/16 09:00 MHDA- 2009/02/26 09:00 CRDT- 2008/09/16 09:00 PHST- 2008/07/18 00:00 [received] PHST- 2008/07/18 00:00 [revised] PHST- 2008/07/20 00:00 [accepted] PHST- 2008/09/16 09:00 [pubmed] PHST- 2009/02/26 09:00 [medline] PHST- 2008/09/16 09:00 [entrez] AID - S0306-9877(08)00390-3 [pii] AID - 10.1016/j.mehy.2008.07.049 [doi] PST - ppublish SO - Med Hypotheses. 2009 Jan;72(1):36-8. doi: 10.1016/j.mehy.2008.07.049. Epub 2008 Sep 11.