PMID- 18790619
OWN - NLM
STAT- MEDLINE
DCOM- 20090105
LR  - 20141120
IS  - 0927-7765 (Print)
IS  - 0927-7765 (Linking)
VI  - 67
IP  - 1
DP  - 2008 Nov 15
TI  - Preparation of poly(N-isopropylacrylamide) emulsion gels and their drug release 
      behaviors.
PG  - 92-8
LID - 10.1016/j.colsurfb.2008.08.003 [doi]
AB  - Stimuli-sensitive drug delivery systems (DDSs) have attracted considerable 
      attention in medical and pharmaceutical fields; thermosensitive DDS dealing with 
      poly(N-isopropylacrylamide) (poly(NIPA)) have been widely studied. Novel NIPA 
      emulsion gels, i.e., NIPA hydrogels containing distributed oil (oleyl alcohol) 
      microdroplets, were synthesized by means of an emulsion-gelation method in which 
      the polymerization of hydrogels in an aqueous phase in an oil-in-water (O/W) 
      emulsion and the loading of a lipophilic drug (indomethacin) dissolved in an oil 
      phase were accomplished simultaneously. The pulsatile (on-off) drug release from 
      the NIPA emulsion gel loading indomethacin to a phosphate buffered saline (PBS) 
      solution was successfully controlled by a temperature swing between 25 degrees C 
      (release off) and 40 degrees C (release on). The mechanism of the pulsatile drug 
      release was discussed in relation to the diffusion rate, distribution ratio, 
      solvent exchange of NIPA hydrogels, and drug release from an NIPA organogel. The 
      mechanism was as follows: the solvent exchange occurred within the NIPA emulsion 
      gel (the NIPA gel-network absorbed oleyl alcohol with indomethacin) at 
      temperatures above the LCST, and the diffusion rate of indomethacin through the 
      solvent-exchanged gel was higher at 40 degrees C than at 25 degrees C.
FAU - Tokuyama, Hideaki
AU  - Tokuyama H
AD  - Department of Chemical Engineering, Graduate School of Engineering, Nagoya 
      University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. 
      htoku@nuce.nagoya-u.ac.jp
FAU - Kato, Yuya
AU  - Kato Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080814
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Acrylamides)
RN  - 0 (Acrylic Resins)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Emulsions)
RN  - 0 (Fatty Alcohols)
RN  - 0 (Gels)
RN  - 0 (Polymers)
RN  - 172F2WN8DV (oleyl alcohol)
RN  - 25189-55-3 (poly-N-isopropylacrylamide)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Acrylamides/*chemical synthesis
MH  - Acrylic Resins
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacokinetics
MH  - *Drug Delivery Systems
MH  - Emulsions
MH  - Fatty Alcohols
MH  - Gels
MH  - Indomethacin/*pharmacokinetics
MH  - Polymers/*chemical synthesis
EDAT- 2008/09/16 09:00
MHDA- 2009/01/06 09:00
CRDT- 2008/09/16 09:00
PHST- 2008/05/22 00:00 [received]
PHST- 2008/07/31 00:00 [revised]
PHST- 2008/08/05 00:00 [accepted]
PHST- 2008/09/16 09:00 [pubmed]
PHST- 2009/01/06 09:00 [medline]
PHST- 2008/09/16 09:00 [entrez]
AID - S0927-7765(08)00290-7 [pii]
AID - 10.1016/j.colsurfb.2008.08.003 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2008 Nov 15;67(1):92-8. doi: 
      10.1016/j.colsurfb.2008.08.003. Epub 2008 Aug 14.