PMID- 18793678
OWN - NLM
STAT- MEDLINE
DCOM- 20090410
LR  - 20081223
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 197
IP  - 1
DP  - 2009 Jan 30
TI  - Higher BDNF concentrations in the hippocampus and cortex of an aggressive mouse 
      strain.
PG  - 246-9
LID - 10.1016/j.bbr.2008.08.025 [doi]
AB  - Although genetically closely related AB-Halle (ABH) and AB-Gatersleben (ABG) mice 
      inbred strains differ in activity and aggressive behaviour. These behavioural 
      traits have been observed especially in response to social challenges, where ABH 
      mice develop a highly aggressive and active behaviour, which cannot be observed 
      in their ABG counterparts. In contrast to ABG mice, basal brain serotonin, 
      dopamine and noradrenaline concentrations in ABH mice are low but highly 
      stimulated by social challenges. Since brain-derived neurotrophic factor (BDNF) 
      modulates central neurotransmitter systems and has been involved in aggressive 
      and activity behaviour, we studied specific concentrations of BDNF and NGF 
      protein in several brain regions of ABG and ABH mice. A significant higher 
      concentration of BDNF protein was found in the hippocampus of 5 weeks and 5 
      months old ABH mice, when compared to ABG mice. BDNF was also higher in the 
      cortex of 5 weeks and 5 months old ABH mice. Moreover BDNF concentrations were 
      higher in the striatum of 5 months old ABH mice when compared to ABG mice. NGF 
      concentrations in ABH mice were not changed in all measured brain regions but 
      higher in older age in the hippocampus of ABG mice as compared to ABH mice. We 
      hypothesize, that BDNF might be involved in the behavioural and neurochemical 
      mechanisms of aggressive behaviour.
FAU - Lang, Undine E
AU  - Lang UE
AD  - Department of Psychiatry and Psychotherapy, Charite Medicine Berlin, Campus 
      Mitte, Chariteplatz 1, 10119 Berlin, Germany.
FAU - Gunther, Lydia
AU  - Gunther L
FAU - Scheuch, Kathrin
AU  - Scheuch K
FAU - Klein, Julia
AU  - Klein J
FAU - Eckhart, Sarah
AU  - Eckhart S
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Danker-Hopfe, Heidi
AU  - Danker-Hopfe H
FAU - Oehler, Jochen
AU  - Oehler J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080828
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Aggression/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/*metabolism
MH  - Hippocampus/*metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motor Activity/physiology
MH  - Neostriatum/metabolism
MH  - Species Specificity
EDAT- 2008/09/17 09:00
MHDA- 2009/04/11 09:00
CRDT- 2008/09/17 09:00
PHST- 2008/07/14 00:00 [received]
PHST- 2008/08/18 00:00 [revised]
PHST- 2008/08/22 00:00 [accepted]
PHST- 2008/09/17 09:00 [pubmed]
PHST- 2009/04/11 09:00 [medline]
PHST- 2008/09/17 09:00 [entrez]
AID - S0166-4328(08)00474-9 [pii]
AID - 10.1016/j.bbr.2008.08.025 [doi]
PST - ppublish
SO  - Behav Brain Res. 2009 Jan 30;197(1):246-9. doi: 10.1016/j.bbr.2008.08.025. Epub 
      2008 Aug 28.