PMID- 18795630
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20111117
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 30
IP  - 4
DP  - 2008 Aug
TI  - [Influence of short-term high-fat diet on glucose and lipid metabolism in male 
      Han Chinese with type 2 diabetes mellitus].
PG  - 509-15
AB  - OBJECTIVE: To investigate the influence of short-term high-fat diet (HFD) on 
      glucose and lipid metabolism in male Han Chinese with type 2 diabetes mellitus 
      (T2DM). METHODS: Middle-aged T2DM men supported with solely diet or diet and 
      metformin were enrolled into the study. The design was an unblinded crossover 
      design. Each of the subjects randomly received one from two types of isocalorie 
      (8786.4 kJ/d) standard diet for three consecutive days on two occasions, with a 
      6-week wash-out period in between. The component ratios of fat, carbohydrate, and 
      protein were 50%, 35%, and 15% vs. 25%, 60%, and 15% in patients administered 
      with HFD or high carbohydrate diet (HCD). The 24-hour blood samples during the 
      third day were collected. On the morning of the forth day an intravenous glucose 
      tolerance test (IVGTT) was conducted with 25g of glucose. RESULTS: According to 
      the determination results of 24-hour profile samples, HFD resulted in a markedly 
      increased circulating level of non-esterified fatty acid (NEFA) as compared to 
      HCD (P < 0.001). Nearly significant higher (P = 0.056) FPG was observed 72 hours 
      after the administration of HFD. Circulating insulin levels were comparable 
      between the two diets. A significantly higher HDL-C was also observed after HFD 
      administration (P < 0.05). As assessed by the IVGTT, acute insulin response of 
      glucose (AIRg) tended to increase after the HFD administration (P = 0.06). 
      Fasting plasma glucagons (GLG) level and AUC(Glucagon) during breakfast period 
      (8:00-12:00) were significantly higher after HFD administration than that of 
      after HCD administration. CONCLUSIONS: Short-term HFD induced the increase of 
      NEFA with lower glucose exposure to the patietns. Fasting plasma glucose 
      increased at the fourth day without remarkable changes of insulin levels which 
      may be due to the increase of hepatic glucose output after HFD administration. 
      The short-term HFD in our study induced early stage of insulin resistance. GLG 
      seemed to play a role in this procedure. beta-cell dysfunction may need a longer 
      high NEFA exposure.
FAU - Li, Wen-hui
AU  - Li WH
AD  - Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. 
      liwh@pumch.cn
FAU - Xiao, Xin-hua
AU  - Xiao XH
FAU - Yu, Kang
AU  - Yu K
FAU - Sun, Qi
AU  - Sun Q
FAU - Yang, Guo-hua
AU  - Yang GH
FAU - Wang, Heng
AU  - Wang H
FAU - Ole, Schmitz
AU  - Ole S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - China
MH  - Diabetes Mellitus, Type 2/*ethnology/*metabolism
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Fatty Acids, Nonesterified/*metabolism
MH  - Humans
MH  - Insulin/metabolism
MH  - Male
MH  - Middle Aged
EDAT- 2008/09/18 09:00
MHDA- 2010/06/04 06:00
CRDT- 2008/09/18 09:00
PHST- 2008/09/18 09:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
PHST- 2008/09/18 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Aug;30(4):509-15.