PMID- 18797122 OWN - NLM STAT- MEDLINE DCOM- 20090107 LR - 20190606 IS - 1349-7235 (Electronic) IS - 0918-2918 (Linking) VI - 47 IP - 18 DP - 2008 TI - Mediastinal seminoma in a patient with multiple endocrine neoplasia type 1. PG - 1615-9 AB - A patient with multiple endocrine neoplasia type 1 (MEN1) developed a mediastinal seminoma. The patient was a 46-year-old man who presented with respiratory symptoms. A diagnosis of mediastinal seminoma was pathologically confirmed and a complete remission was achieved by chemotherapy. During his hospital stay, hyperparathyroidism and multiple pancreatic tumors associated with hypergastrinemia were found. A diagnosis of MEN1 was made genetically. Although patients with MEN1 manifest a variety of neoplastic disorders, no cases of concurrent seminoma and MEN1 have previously been reported. In addition, no etiological relationship between seminoma and MEN1 has yet been reported. FAU - Tanabe, Tsuyoshi AU - Tanabe T AD - The First Department of Internal Medicine, Shinshu University School of Medicine, and Shinhu University Hospital, Matsumoto. tanatuyo@shinshu-u.ac.jp FAU - Yasuo, Masanori AU - Yasuo M FAU - Tsushima, Kenji AU - Tsushima K FAU - Urushihata, Kazuhisa AU - Urushihata K FAU - Yamamoto, Hiroshi AU - Yamamoto H FAU - Hanaoka, Masayuki AU - Hanaoka M FAU - Koizumi, Tomonobu AU - Koizumi T FAU - Fujimoto, Keisaku AU - Fujimoto K FAU - Yamazaki, Yoshitaka AU - Yamazaki Y FAU - Hirose, Yoshiki AU - Hirose Y FAU - Hamano, Hideaki AU - Hamano H FAU - Sakurai, Akihiro AU - Sakurai A FAU - Kubo, Keishi AU - Kubo K LA - eng PT - Case Reports PT - Journal Article DEP - 20080916 PL - Japan TA - Intern Med JT - Internal medicine (Tokyo, Japan) JID - 9204241 SB - IM MH - Humans MH - Male MH - Mediastinal Neoplasms/*diagnosis/drug therapy/pathology MH - Middle Aged MH - Multiple Endocrine Neoplasia Type 1/*diagnosis MH - Neoplasms, Multiple Primary/*diagnosis/drug therapy MH - Remission Induction MH - Seminoma/*diagnosis/drug therapy/pathology EDAT- 2008/09/18 09:00 MHDA- 2009/01/08 09:00 CRDT- 2008/09/18 09:00 PHST- 2008/09/18 09:00 [pubmed] PHST- 2009/01/08 09:00 [medline] PHST- 2008/09/18 09:00 [entrez] AID - JST.JSTAGE/internalmedicine/47.1226 [pii] AID - 10.2169/internalmedicine.47.1226 [doi] PST - ppublish SO - Intern Med. 2008;47(18):1615-9. doi: 10.2169/internalmedicine.47.1226. Epub 2008 Sep 16.