PMID- 18797871
OWN - NLM
STAT- MEDLINE
DCOM- 20090819
LR  - 20211020
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 29
IP  - 4
DP  - 2009 Feb
TI  - Diagnostic performance of minor salivary gland biopsy, serological and clinical 
      data in Sjogren's syndrome: a retrospective analysis.
PG  - 403-9
LID - 10.1007/s00296-008-0698-1 [doi]
AB  - The aim of this study was to investigate the performance of minor salivary gland 
      biopsy (MSGB), serological and clinical data in diagnosis of primary Sjogren's 
      syndrome (pSS). Retrospective review of 216 patients who underwent minor labial 
      salivary gland biopsy in last 5 years was performed. Results of the patients with 
      diagnosis of pSS were compared with the patients failing to fill the 
      classification criteria of pSS. Two groups did not differ significantly in terms 
      of clinical symptoms and signs except presence of Raynaud's phenomenon. 
      Specificity and positive likelihood ratio of clinical signs in diagnosis of pSS 
      were quiet low. A total of 78.7% of pSS patients had a focus score >or=1 
      (Chiscolm's score III/IV) while all of the non-SS patients had a focus score <1 
      (P < 0.001). MSGB has the best predictive value with highest sensitivity and 
      specificity for pSS diagnosis. Serological markers have higher predictive values 
      compared to clinical symptoms and signs. Presence of Raynaud's phenomenon, 
      lymphopenia and/or hypergammaglobulinemia strengthens the probability of pSS in a 
      patient with sicca symptoms.
FAU - Yazisiz, Veli
AU  - Yazisiz V
AD  - Division of Rheumatology and Immunology, Department of Internal Medicine, 
      University of Akdeniz, Antalya, Turkey. drveliyazisiz60@hotmail.com
FAU - Avci, Ali Berkant
AU  - Avci AB
FAU - Erbasan, Funda
AU  - Erbasan F
FAU - Kiris, Evren
AU  - Kiris E
FAU - Terzioglu, Ender
AU  - Terzioglu E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080918
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Antibodies, Antinuclear/blood
MH  - Arthralgia/*diagnosis
MH  - Biomarkers/blood
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - Hypergammaglobulinemia/blood
MH  - Immunoglobulin G/*blood
MH  - Immunoglobulin M/*blood
MH  - Lymphopenia/blood
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Reference Values
MH  - Retrospective Studies
MH  - Rheumatoid Factor/blood
MH  - Saliva/chemistry
MH  - Salivary Glands, Minor/*pathology
MH  - Sensitivity and Specificity
MH  - Sjogren's Syndrome/*diagnosis/immunology/pathology
EDAT- 2008/09/18 09:00
MHDA- 2009/08/20 09:00
CRDT- 2008/09/18 09:00
PHST- 2008/06/22 00:00 [received]
PHST- 2008/09/03 00:00 [accepted]
PHST- 2008/09/18 09:00 [pubmed]
PHST- 2009/08/20 09:00 [medline]
PHST- 2008/09/18 09:00 [entrez]
AID - 10.1007/s00296-008-0698-1 [doi]
PST - ppublish
SO  - Rheumatol Int. 2009 Feb;29(4):403-9. doi: 10.1007/s00296-008-0698-1. Epub 2008 
      Sep 18.