PMID- 18798064
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20131121
IS  - 1532-4192 (Electronic)
IS  - 0735-7907 (Linking)
VI  - 26
IP  - 8
DP  - 2008 Oct
TI  - Overexpression of high mobility group (HMG) B1 and B2 proteins directly 
      correlates with the progression of squamous cell carcinoma in skin.
PG  - 843-51
LID - 10.1080/07357900801954210 [doi]
AB  - High mobility group B (HMGB) chromosomal proteins, which plays important role in 
      cancer and inflammation, were followed at various stages of the squamous cell 
      carcinoma of skin. Present results were analyzed by histopathology, BrdU assay, 
      immunohistochemistry, western blot and RT-PCR, which indicate that at early 
      stages of tumorigenesis, expression of HMGB (B1, B2), raised only by about 20%. 
      However, the advanced (> or =12 weeks) tumors showed significant (> or =80%) 
      increase in HMG levels. Using skin cancer model, we demonstrated that high levels 
      of HMGB directly correlate with the extent of neoplastic changes, and it appears 
      that HMGB is an effective stimulus for cell differentiation, tumor progression, 
      and metastatic invasion.
FAU - Sharma, Ashok
AU  - Sharma A
AD  - Departments of Biochemistry, All India Institute of Medical Science, New Delhi, 
      India.
FAU - Ray, Ruma
AU  - Ray R
FAU - Rajeswari, Moganty R
AU  - Rajeswari MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cancer Invest
JT  - Cancer investigation
JID - 8307154
RN  - 0 (HMGB1 Protein)
RN  - 0 (HMGB2 Protein)
RN  - 0 (Neoplasm Proteins)
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Animals
MH  - Benzo(a)pyrene
MH  - Carcinoma, Squamous Cell/chemically induced/*chemistry/pathology
MH  - Cell Differentiation
MH  - DNA Replication
MH  - Disease Progression
MH  - Female
MH  - HMGB1 Protein/*analysis/physiology
MH  - HMGB2 Protein/*analysis/physiology
MH  - Mice
MH  - Neoplasm Invasiveness
MH  - Neoplasm Proteins/*analysis/physiology
MH  - Skin Neoplasms/chemically induced/*chemistry/pathology
EDAT- 2008/09/18 09:00
MHDA- 2008/11/18 09:00
CRDT- 2008/09/18 09:00
PHST- 2008/09/18 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/09/18 09:00 [entrez]
AID - 902506880 [pii]
AID - 10.1080/07357900801954210 [doi]
PST - ppublish
SO  - Cancer Invest. 2008 Oct;26(8):843-51. doi: 10.1080/07357900801954210.