PMID- 18799141
OWN - NLM
STAT- MEDLINE
DCOM- 20081016
LR  - 20211020
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 29
IP  - 3
DP  - 2008 Sep 19
TI  - Mechanisms and consequences of dendritic cell migration.
PG  - 325-42
LID - 10.1016/j.immuni.2008.08.006 [doi]
AB  - Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs 
      are strategically positioned as immune sentinels poised to respond to invading 
      pathogens in tissues throughout the body. Differentiated DCs and their precursors 
      also circulate in blood and can get rapidly recruited to sites of challenge. 
      Within peripheral tissues, DCs collect antigenic material and then traffic to 
      secondary lymphoid organs, where they communicate with lymphocytes to orchestrate 
      adaptive immune responses. Hence, the migration and accurate positioning of DCs 
      is indispensable for immune surveillance. Here, we review the molecular traffic 
      signals that govern the migration of DCs throughout their life cycle.
FAU - Alvarez, David
AU  - Alvarez D
AD  - Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
FAU - Vollmann, Elisabeth H
AU  - Vollmann EH
FAU - von Andrian, Ulrich H
AU  - von Andrian UH
LA  - eng
GR  - R01 AI069259-04/AI/NIAID NIH HHS/United States
GR  - R01 AI069259-02/AI/NIAID NIH HHS/United States
GR  - P01 AI078897-019002/AI/NIAID NIH HHS/United States
GR  - R01 AI072252-02/AI/NIAID NIH HHS/United States
GR  - P01 HL056949-040003/HL/NHLBI NIH HHS/United States
GR  - P01 HL056949-050003/HL/NHLBI NIH HHS/United States
GR  - R01 AI069259-01/AI/NIAID NIH HHS/United States
GR  - R01 AI072252-01/AI/NIAID NIH HHS/United States
GR  - P01 HL056949/HL/NHLBI NIH HHS/United States
GR  - P01 HL056949-030003/HL/NHLBI NIH HHS/United States
GR  - P01 HL056949-080003/HL/NHLBI NIH HHS/United States
GR  - R01 AI072252-03/AI/NIAID NIH HHS/United States
GR  - P01 HL056949-090003/HL/NHLBI NIH HHS/United States
GR  - P01 AI078897-02S1/AI/NIAID NIH HHS/United States
GR  - P01 HL056949-070003/HL/NHLBI NIH HHS/United States
GR  - P01 HL56949/HL/NHLBI NIH HHS/United States
GR  - P01 AI078897-020001/AI/NIAID NIH HHS/United States
GR  - R01 AI072252-03S1/AI/NIAID NIH HHS/United States
GR  - P01 AI078897/AI/NIAID NIH HHS/United States
GR  - R01 AI069259-05/AI/NIAID NIH HHS/United States
GR  - P01 HL056949-100003/HL/NHLBI NIH HHS/United States
GR  - P01 AI078897-02/AI/NIAID NIH HHS/United States
GR  - R01 AI072252/AI/NIAID NIH HHS/United States
GR  - R01 AI069259/AI/NIAID NIH HHS/United States
GR  - P01 HL056949-060003/HL/NHLBI NIH HHS/United States
GR  - P01 AI078897-02S17019/AI/NIAID NIH HHS/United States
GR  - P01 AI078897-029002/AI/NIAID NIH HHS/United States
GR  - R01 AI069259-03/AI/NIAID NIH HHS/United States
GR  - P01 AI078897-010001/AI/NIAID NIH HHS/United States
GR  - P01 HL056949-020003/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Animals
MH  - *Cell Movement
MH  - Chemotactic Factors/immunology/metabolism
MH  - *Chemotaxis
MH  - Cytokines/immunology/*metabolism
MH  - Dendritic Cells/*immunology/physiology
MH  - Humans
MH  - Lymphoid Tissue/*immunology
MH  - Receptors, Chemokine/immunology/metabolism
MH  - Signal Transduction
MH  - Spleen/cytology/immunology
PMC - PMC2818978
MID - NIHMS168091
EDAT- 2008/09/19 09:00
MHDA- 2008/10/17 09:00
PMCR- 2010/02/10
CRDT- 2008/09/19 09:00
PHST- 2008/09/19 09:00 [pubmed]
PHST- 2008/10/17 09:00 [medline]
PHST- 2008/09/19 09:00 [entrez]
PHST- 2010/02/10 00:00 [pmc-release]
AID - S1074-7613(08)00377-4 [pii]
AID - 10.1016/j.immuni.2008.08.006 [doi]
PST - ppublish
SO  - Immunity. 2008 Sep 19;29(3):325-42. doi: 10.1016/j.immuni.2008.08.006.