PMID- 18801036
OWN - NLM
STAT- MEDLINE
DCOM- 20090408
LR  - 20131121
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 49
IP  - 12
DP  - 2008 Dec
TI  - Carbamazepine-induced drug-induced hypersensitivity syndrome in a 14-year-old 
      Japanese boy.
PG  - 2118-21
LID - 10.1111/j.1528-1167.2008.01785.x [doi]
AB  - Drug-induced hypersensitivity syndrome (DIHS) is a life-threatening idiosyncratic 
      drug reaction, and an early accurate diagnosis is essential for its treatment. We 
      describe a 14-year-old boy with localization-related epilepsy, who developed 
      severe adverse cutaneous and systemic reactions after 3 weeks of carbamazepine 
      administration. During the course of the clinical symptoms, reactivation of human 
      herpesvirus 6 (HHV-6) was proven by detection of the HHV-6 genome in serum and 
      elevation of HHV-6 immunoglobulin G (IgG). He fulfilled the newly established 
      criteria for DIHS. Among eight identified medications that can precipitate DIHS, 
      four are antiepileptic drugs. Establishing a treatment strategy for DIHS is 
      warranted to improve its outcome. Therefore, it is important to raise awareness 
      of DIHS among epileptologists.
FAU - Suzuki, Yuka
AU  - Suzuki Y
AD  - Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, 
      Ehime, Japan. yusuzuki@m.ehime-u.ac.jp
FAU - Fukuda, Mitsumasa
AU  - Fukuda M
FAU - Tohyama, Mikiko
AU  - Tohyama M
FAU - Ishikawa, Manami
AU  - Ishikawa M
FAU - Yasukawa, Masaki
AU  - Yasukawa M
FAU - Ishii, Eiichi
AU  - Ishii E
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080917
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
RN  - 33CM23913M (Carbamazepine)
SB  - IM
MH  - Adolescent
MH  - Anticonvulsants/*adverse effects
MH  - Carbamazepine/*adverse effects
MH  - Drug Hypersensitivity/*etiology
MH  - Epilepsy/drug therapy
MH  - Erythema/chemically induced
MH  - Herpesvirus 6, Human/genetics/isolation & purification
MH  - Humans
MH  - Male
MH  - Roseolovirus Infections/complications
EDAT- 2008/09/20 09:00
MHDA- 2009/04/09 09:00
CRDT- 2008/09/20 09:00
PHST- 2008/09/20 09:00 [pubmed]
PHST- 2009/04/09 09:00 [medline]
PHST- 2008/09/20 09:00 [entrez]
AID - EPI1785 [pii]
AID - 10.1111/j.1528-1167.2008.01785.x [doi]
PST - ppublish
SO  - Epilepsia. 2008 Dec;49(12):2118-21. doi: 10.1111/j.1528-1167.2008.01785.x. Epub 
      2008 Sep 17.