PMID- 18801086
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20080919
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 58
IP  - 10
DP  - 2008 Oct
TI  - Hypopharyngeal squamous cell carcinoma producing both granulocyte 
      colony-stimulating factor and parathyroid hormone-related protein.
PG  - 652-6
LID - 10.1111/j.1440-1827.2008.02285.x [doi]
AB  - A 57-year-old woman was admitted to Hokkaido University Hospital because of 
      dysphagia. Laryngoscopy indicated hypopharyngeal tumor histologically diagnosed 
      as squamous cell carcinoma (SCC). A combination of radiotherapy and chemotherapy 
      was performed for 2 months, and the hypopharyngeal lesion completely regressed. 
      After 4 months, fever, anorexia, and malaise appeared, and chest X-ray and CT 
      indicated two large tumors in the right lung. Transbroncheal lung biopsy (TBLB) 
      specimens were diagnosed as SCC. Laboratory data showed high levels of serum 
      granulocyte colony-stimulating factor (G-CSF) and parathyroid hormone-related 
      protein (PTHrP). Subsequently, positron emission tomography (PET) showed multiple 
      metastases to several organs including the liver, spine, skull, and thigh. Two 
      months after readmission, the patient died with no success of chemotherapy. At 
      autopsy, the lung tumor was clearly positive for both G-CSF and PTHrP on 
      immunohistostaining. Retrospectively, examination showed that the primary 
      pharyngeal tumor was focally positive for these two cytokines. Thus, a certain 
      population of hypopharyngeal cancer producing G-CSF and PTHrP, spread to various 
      organs and contributed to the rapid progression and poor prognosis. This case is 
      presented with a discussion of several other cases in the literature.
FAU - Tamura, Kanae
AU  - Tamura K
AD  - Laboratory of Molecular and Cellular Pathology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan. tanaka@med.hokudai.ac.jp
FAU - Yoshinaga, Tomoaki
AU  - Yoshinaga T
FAU - Tanino, Mishie
AU  - Tanino M
FAU - Kimura, Taichi
AU  - Kimura T
FAU - Yamada, Noriyuki
AU  - Yamada N
FAU - Nishimura, Masaharu
AU  - Nishimura M
FAU - Fukuda, Satoshi
AU  - Fukuda S
FAU - Nishihara, Hiroshi
AU  - Nishihara H
FAU - Shindoh, Masanobu
AU  - Shindoh M
FAU - Tanaka, Shinya
AU  - Tanaka S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Parathyroid Hormone-Related Protein)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/secondary/therapy
MH  - Combined Modality Therapy
MH  - Deglutition Disorders/pathology
MH  - Fatal Outcome
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/*blood
MH  - Humans
MH  - Hypopharyngeal Neoplasms/*metabolism/pathology/therapy
MH  - Lung Neoplasms/metabolism/secondary
MH  - Middle Aged
MH  - Parathyroid Hormone-Related Protein/*blood
EDAT- 2008/09/20 09:00
MHDA- 2008/10/31 09:00
CRDT- 2008/09/20 09:00
PHST- 2008/09/20 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2008/09/20 09:00 [entrez]
AID - PIN2285 [pii]
AID - 10.1111/j.1440-1827.2008.02285.x [doi]
PST - ppublish
SO  - Pathol Int. 2008 Oct;58(10):652-6. doi: 10.1111/j.1440-1827.2008.02285.x.