PMID- 18801851
OWN - NLM
STAT- MEDLINE
DCOM- 20090122
LR  - 20240415
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Print)
IS  - 0031-9023 (Linking)
VI  - 88
IP  - 11
DP  - 2008 Nov
TI  - Comparison of combined aerobic and high-force eccentric resistance exercise with 
      aerobic exercise only for people with type 2 diabetes mellitus.
PG  - 1345-54
LID - 10.2522/ptj.20080124 [doi]
AB  - BACKGROUND AND PURPOSE: The purpose of this study was to compare the outcomes 
      between a diabetes exercise training program using combined aerobic and 
      high-force eccentric resistance exercise and a program of aerobic exercise only. 
      SUBJECTS AND METHODS: Fifteen participants with type 2 diabetes mellitus (T2DM) 
      participated in a 16-week supervised exercise training program: 7 (mean age=50.7 
      years, SD=6.9) in a combined aerobic and eccentric resistance exercise program 
      (AE/RE group) and 8 (mean age=58.5 years, SD=6.2) in a program of aerobic 
      exercise only (AE group). Outcome measures included thigh lean tissue and 
      intramuscular fat (IMF), glycosylated hemoglobin, body mass index (BMI), and 
      6-minute walk distance. RESULTS: Both groups experienced decreases in mean 
      glycosylated hemoglobin after training (AE/RE group: -0.59% [95% confidence 
      interval (CI)=-1.5 to 0.28]; AE group: -0.31% [95% CI=-0.60 to -0.03]), with no 
      significant between-group differences. There was an interaction between group and 
      time with respect to change in thigh lean tissue cross-sectional area, with the 
      AE/RE group gaining more lean tissue (AE/RE group: 15.1 cm(2) [95% CI=7.6 to 
      22.5]; AE group: -5.6 cm(2) [95% CI=-10.4 to 0.76]). Both groups experienced 
      decreases in mean thigh IMF cross-sectional area (AE/RE group: -1.2 cm(2) [95% 
      CI=-2.6 to 0.26]; AE group: -2.2 cm(2) [95% CI=-3.5 to -0.84]) and increases in 
      6-minute walk distance (AE/RE group: 45.5 m [95% CI=7.5 to 83.6]; AE group: 29.9 
      m [95% CI=-7.7 to 67.5]) after training, with no between-group differences. There 
      was an interaction between group and time with respect to change in BMI, with the 
      AE/RE group experiencing a greater decrease in BMI. DISCUSSION AND CONCLUSION: 
      Significant improvements in long-term glycemic control, thigh composition, and 
      physical performance were demonstrated in both groups after participating in a 
      16-week exercise program. SUBJECTS: in the AE/RE group demonstrated additional 
      improvements in thigh lean tissue and BMI. Improvements in thigh lean tissue may 
      be important in this population as a means to increase resting metabolic rate, 
      protein reserve, exercise tolerance, and functional mobility.
FAU - Marcus, Robin L
AU  - Marcus RL
AD  - Department of Physical Therapy and Department of Exercise and Sport Science, 
      University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA. 
      robin.marcus@hsc.utah.edu
FAU - Smith, Sheldon
AU  - Smith S
FAU - Morrell, Glen
AU  - Morrell G
FAU - Addison, Odessa
AU  - Addison O
FAU - Dibble, Leland E
AU  - Dibble LE
FAU - Wahoff-Stice, Donna
AU  - Wahoff-Stice D
FAU - Lastayo, Paul C
AU  - Lastayo PC
LA  - eng
GR  - 5K12HD043449-04/HD/NICHD NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080918
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
EIN - Phys Ther. 2009 Jan;89(1):103
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*therapy
MH  - Exercise/*physiology
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC2579905
EDAT- 2008/09/20 09:00
MHDA- 2009/01/23 09:00
PMCR- 2009/05/01
CRDT- 2008/09/20 09:00
PHST- 2008/09/20 09:00 [pubmed]
PHST- 2009/01/23 09:00 [medline]
PHST- 2008/09/20 09:00 [entrez]
PHST- 2009/05/01 00:00 [pmc-release]
AID - ptj.20080124 [pii]
AID - 2740 [pii]
AID - 10.2522/ptj.20080124 [doi]
PST - ppublish
SO  - Phys Ther. 2008 Nov;88(11):1345-54. doi: 10.2522/ptj.20080124. Epub 2008 Sep 18.