PMID- 18802009
OWN - NLM
STAT- MEDLINE
DCOM- 20090112
LR  - 20231213
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 112
IP  - 12
DP  - 2008 Dec 1
TI  - Estrogen inhibits dendritic cell maturation to RNA viruses.
PG  - 4574-84
LID - 10.1182/blood-2008-04-148692 [doi]
AB  - Dendritic cells (DCs) play a central role in initiating and polarizing the immune 
      response. Therefore, DC maturation represents a key control point in the shift 
      from innate to adaptive immunity. It is suspected that during pregnancy, hormones 
      are critical factors that modulate changes reported to occur in maternal 
      immunity. Here we examined the effect of 17-beta-estradiol (E2) on the 
      maturational response triggered by virus in human DCs and its influence on their 
      ability to activate naive T cells. We developed an in vitro system to measure the 
      response of DCs to virus infection with Newcastle disease virus (NDV) after a 
      24-hour E2 treatment. Using this system, we demonstrated that E2 pretreatment 
      down-regulated the antiviral response to RNA viruses in DCs by profoundly 
      suppressing type I interferon (IFN) synthesis and other important inflammatory 
      products. In addition, the DCs capacity to stimulate naive CD4 T cells was also 
      reduced. These results suggest an important role for E2 in suppressing the 
      antiviral response and provide a mechanism for the reduced immunity to virus 
      infection observed during pregnancy.
FAU - Escribese, Maria M
AU  - Escribese MM
AD  - Department of Microbiology, The Immunology Institute, Mount Sinai School of 
      Medicine, New York, NY 10029, USA.
FAU - Kraus, Thomas
AU  - Kraus T
FAU - Rhee, Esther
AU  - Rhee E
FAU - Fernandez-Sesma, Ana
AU  - Fernandez-Sesma A
FAU - Lopez, Carolina B
AU  - Lopez CB
FAU - Moran, Thomas M
AU  - Moran TM
LA  - eng
GR  - N01-A1-50028/PHS HHS/United States
GR  - U19 A1062623/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080918
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Toll-Like Receptors)
RN  - 77238-31-4 (Interferon-beta)
RN  - EC 3.6.1.- (RIGI protein, human)
RN  - EC 3.6.4.13 (DEAD Box Protein 58)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
SB  - IM
MH  - Cell Differentiation/drug effects/immunology
MH  - Cells, Cultured
MH  - DEAD Box Protein 58
MH  - DEAD-box RNA Helicases/genetics/metabolism
MH  - Dendritic Cells/*drug effects/immunology/metabolism
MH  - Down-Regulation/drug effects
MH  - Estrogens/*pharmacology
MH  - Humans
MH  - Immunity, Cellular/drug effects/genetics
MH  - Interferon-beta/genetics/pharmacology
MH  - Newcastle disease virus/immunology
MH  - Promoter Regions, Genetic/drug effects
MH  - RNA Virus Infections/immunology
MH  - RNA Viruses/*immunology
MH  - Receptors, Estrogen/genetics/metabolism
MH  - Receptors, Immunologic
MH  - Signal Transduction/drug effects/immunology
MH  - Toll-Like Receptors/agonists/antagonists & inhibitors
PMC - PMC2597128
EDAT- 2008/09/20 09:00
MHDA- 2009/01/13 09:00
PMCR- 2008/12/01
CRDT- 2008/09/20 09:00
PHST- 2008/09/20 09:00 [pubmed]
PHST- 2009/01/13 09:00 [medline]
PHST- 2008/09/20 09:00 [entrez]
PHST- 2008/12/01 00:00 [pmc-release]
AID - S0006-4971(20)51806-5 [pii]
AID - 2008/148692 [pii]
AID - 10.1182/blood-2008-04-148692 [doi]
PST - ppublish
SO  - Blood. 2008 Dec 1;112(12):4574-84. doi: 10.1182/blood-2008-04-148692. Epub 2008 
      Sep 18.