PMID- 18802348
OWN - NLM
STAT- MEDLINE
DCOM- 20090415
LR  - 20221207
IS  - 1660-2242 (Print)
IS  - 0079-6034 (Linking)
VI  - 94
DP  - 2008
TI  - Lung dendritic cells: targets for therapy in allergic disease.
PG  - 189-200
LID - 10.1159/000155087 [doi]
AB  - Dendritic cells (DCs) are crucial in determining the functional outcome of 
      allergen encounter in the lung. Antigen presentation by myeloid DCs leads to Th2 
      sensitization typical of allergic disease, whereas antigen presentation by 
      plasmacytoid DCs serves to dampen inflammation. It is increasingly clear that DCs 
      have an antigen presenting function beyond sensitization. DCs therefore 
      constitute a novel target for the development of antiallergic therapy aimed at 
      the origin of the inflammatory cascade. A careful study of DC biology and of the 
      receptors expressed by lung DCs has provided a framework for the discovery of 
      novel antiallergic compounds.
FAU - Lambrecht, B
AU  - Lambrecht B
AD  - Department of Respiratory Diseases, University Hospital Ghent, Ghent, Belgium, 
      and Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
FAU - Hammad, H
AU  - Hammad H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Chem Immunol Allergy
JT  - Chemical immunology and allergy
JID - 101183835
RN  - 0 (Core Binding Factor Alpha 3 Subunit)
RN  - 0 (Cytokines)
RN  - 0 (Membrane Proteins)
RN  - 0 (Runx3 protein, mouse)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (flt3 ligand protein)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Differentiation
MH  - Core Binding Factor Alpha 3 Subunit/immunology
MH  - Cytokines/immunology/*metabolism
MH  - Dendritic Cells/*immunology/*metabolism/pathology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immune Tolerance
MH  - Lung/immunology/pathology
MH  - Membrane Proteins/genetics/metabolism
MH  - Respiratory Hypersensitivity/genetics/*immunology/*metabolism/therapy
MH  - Signal Transduction
MH  - T-Lymphocytes, Regulatory/immunology/*metabolism/pathology
MH  - Transforming Growth Factor beta/genetics/*metabolism
MH  - Thymic Stromal Lymphopoietin
RF  - 83
EDAT- 2008/09/20 09:00
MHDA- 2009/04/16 09:00
CRDT- 2008/09/20 09:00
PHST- 2008/09/20 09:00 [pubmed]
PHST- 2009/04/16 09:00 [medline]
PHST- 2008/09/20 09:00 [entrez]
AID - 000155087 [pii]
AID - 10.1159/000155087 [doi]
PST - ppublish
SO  - Chem Immunol Allergy. 2008;94:189-200. doi: 10.1159/000155087.