PMID- 18804762
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20181113
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 203
IP  - 2
DP  - 2009 Apr
TI  - Association between IL-6 and the extent of coronary atherosclerosis in the 
      veterans affairs diabetes trial (VADT).
PG  - 610-4
LID - 10.1016/j.atherosclerosis.2008.07.031 [doi]
AB  - AIMS: The aim of the present study was to investigate the association of 
      high-sensitivity C-reactive protein (CRP), interleukin-6 (IL-6) and 
      lipoprotein-associated phospholipase A2 (Lp-PLA2) with the extent of calcified 
      coronary atherosclerosis in patients with type 2 diabetes mellitus (T2DM). 
      MATERIALS AND RESULTS: This is a cross-sectional study of 306 subjects aged 
      40years or older who were enrolled into the veterans affairs diabetes trial 
      (VADT). Calcified coronary atherosclerosis was assessed using electron beam 
      computed tomography scored by the Agatston method. Clinical parameters, 
      traditional cardiovascular risk factors and plasma levels of CRP, IL-6 and 
      Lp-PLA2 were measured at the time of the scan. Coronary artery calcium (CAC) 
      scores increased stepwise across increasing categories of IL-6, but did not 
      change across increasing categories of CRP and Lp-PLA2. After adjustment for 
      traditional cardiovascular risk factors, IL-6 was significantly associated with 
      CAC scores (p=0.05). The association between IL-6 and CAC was largely in those 
      with lower (below the median) abdominal artery calcium (AAC) levels (p=0.04). 
      CONCLUSIONS: Despite a generally higher level of systemic inflammation in T2DM, 
      the inflammatory marker IL-6 remained significantly associated with CAC score, 
      particularly in those subjects with lower AAC scores.
FAU - Saremi, Aramesh
AU  - Saremi A
AD  - Phoenix VA Health Care System, AZ 85012-1892, United States.
FAU - Anderson, Robert J
AU  - Anderson RJ
FAU - Luo, Ping
AU  - Luo P
FAU - Moritz, Thomas E
AU  - Moritz TE
FAU - Schwenke, Dawn C
AU  - Schwenke DC
FAU - Allison, Mathew
AU  - Allison M
FAU - Reaven, Peter D
AU  - Reaven PD
CN  - VADT
LA  - eng
GR  - R01 HL067690-02/HL/NHLBI NIH HHS/United States
GR  - R01 HL070621/HL/NHLBI NIH HHS/United States
GR  - R01 HL067690-03/HL/NHLBI NIH HHS/United States
GR  - HL70621/HL/NHLBI NIH HHS/United States
GR  - P01 HL076491/HL/NHLBI NIH HHS/United States
GR  - R01067690/PHS HHS/United States
GR  - P01 HL77107/HL/NHLBI NIH HHS/United States
GR  - R01 HL067690-01/HL/NHLBI NIH HHS/United States
GR  - R01 HL067690/HL/NHLBI NIH HHS/United States
GR  - P50 HL077107/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080805
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
SB  - IM
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase/*metabolism
MH  - Aged
MH  - Atherosclerosis/immunology/pathology
MH  - C-Reactive Protein/*metabolism
MH  - Calcinosis/pathology
MH  - Cardiovascular Diseases/blood
MH  - Coronary Artery Disease/*complications/*diagnosis
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Risk Factors
PMC - PMC2688903
MID - NIHMS110855
COIS- Duality of interest The authors attest that no conflict of interest or duality 
      exists related to this work.
EDAT- 2008/09/23 09:00
MHDA- 2009/08/26 09:00
PMCR- 2010/04/01
CRDT- 2008/09/23 09:00
PHST- 2008/03/27 00:00 [received]
PHST- 2008/07/24 00:00 [revised]
PHST- 2008/07/28 00:00 [accepted]
PHST- 2008/09/23 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
PHST- 2008/09/23 09:00 [entrez]
PHST- 2010/04/01 00:00 [pmc-release]
AID - S0021-9150(08)00535-2 [pii]
AID - 10.1016/j.atherosclerosis.2008.07.031 [doi]
PST - ppublish
SO  - Atherosclerosis. 2009 Apr;203(2):610-4. doi: 
      10.1016/j.atherosclerosis.2008.07.031. Epub 2008 Aug 5.