PMID- 1880611
OWN - NLM
STAT- MEDLINE
DCOM- 19910930
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 121
IP  - 9
DP  - 1991 Sep
TI  - Dietary (n-3) fatty acids affect rat heart, liver and aorta protective enzyme 
      activities and lipid peroxidation.
PG  - 1331-40
AB  - In a 16-wk study, weanling Wistar rats (32 males and 32 females) were fed a 
      modified AIN-76 diet containing 20% fat with various (n-3) fatty acids. All 
      dietary fats provided the same amount of saturates, monounsaturates, and total 
      essential fatty acids [(n-6) + (n-3)]. The control diet contained lard/corn oil 
      (L/CO). The other diets contained (n-3) fatty acids from linseed oil (LSO), from 
      linseed oil + menhaden oil (LSO + MO) or from menhaden oil (MO). The (n-3) diets 
      reduced total and HDL-cholesterol, particularly in rats fed the MO diet. Platelet 
      thromboxane levels were equally depressed by the LSO and MO diets. Dietary (n-3) 
      fatty acids significantly elevated docosahexaenoic acid in livers and hearts of 
      male and female rats, with females reaching higher levels. This increase was 
      accompanied by reduced arachidonic acid, except for hearts of females in which 
      the major decrease was in linoleic acid. Overall, enzyme activities in the MO-fed 
      group were decreased to the following levels (relative to the activity in the 
      control group): heart Mn superoxide dismutase (SOD), 28%; liver CuZnSOD, 82%; 
      aorta CuZnSOD, 32%. Greater reductions in these enzyme activities were seen in 
      the female rats fed the MO diet compared with male rats. Lipid peroxidation, 
      assessed by urinary, heart and liver thiobarbituric acid reactants, was increased 
      by dietary (n-3) fatty acids (MO greater than LSO + MO greater than LSO greater 
      than L/CO) and was higher in females than in males. These results indicate that 
      enhanced lipid peroxidation occurs with the increased oxidative stress of 
      elevated tissue (n-3) fatty acids accompanied by reduced SOD activity.
FAU - L'Abbe, M R
AU  - L'Abbe MR
AD  - Nutrition Research Division, Health and Welfare Canada, Ottawa, Ontario.
FAU - Trick, K D
AU  - Trick KD
FAU - Beare-Rogers, J L
AU  - Beare-Rogers JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
CIN - J Nutr. 1992 Aug;122(8):1748-9. PMID: 1640271
MH  - Animals
MH  - Aorta/*drug effects
MH  - Cholesterol/blood
MH  - Dietary Fats/administration & dosage/*pharmacology
MH  - Fatty Acids/administration & dosage/pharmacokinetics/*pharmacology
MH  - Fatty Acids, Omega-3/administration & dosage/pharmacology
MH  - Female
MH  - Glutathione Peroxidase/metabolism
MH  - Heart/*drug effects
MH  - Lipid Peroxidation/*drug effects
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sex Factors
MH  - Superoxide Dismutase/*metabolism
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 10.1093/jn/121.9.1331 [doi]
PST - ppublish
SO  - J Nutr. 1991 Sep;121(9):1331-40. doi: 10.1093/jn/121.9.1331.