PMID- 18806688
OWN - NLM
STAT- MEDLINE
DCOM- 20081126
LR  - 20181113
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 19
IP  - 16
DP  - 2008 Oct 29
TI  - Splenium microstructure is related to two dimensions of reading skill.
PG  - 1627-31
LID - 10.1097/WNR.0b013e328314b8ee [doi]
AB  - Inconsistent differences in the corpus callosum (CC) structure between dyslexic 
      readers (DRs) and typical readers (TRs) have been reported. We examine 
      differences in CC splenium microstructure and the association of splenium 
      microstructure with reading-related skills. Nine DRs and 18 TRs completed a 
      reading skills battery and diffusion tensor imaging. DRs had higher splenium 
      fractional anisotropy (FA) and axial diffusivity (LA) as compared with TRs. 
      Retrieval of orthographic information from the language lexicon was negatively 
      associated with FA and LA within both reading groups. Phonological awareness was 
      positively associated with splenium FA and LA in TRs but not DRs. This study 
      suggests two white matter pathways that may be differentially associated with 
      reading skills in the CC splenium.
FAU - Frye, Richard E
AU  - Frye RE
AD  - Department of Pediatrics, University of Texas Health Science Center, 7000 
      Fannin-UCT 2478, Houston, TX 77030, USA. Richard.E.Frye@uth.tmc.edu
FAU - Hasan, Khader
AU  - Hasan K
FAU - Xue, Lian
AU  - Xue L
FAU - Strickland, David
AU  - Strickland D
FAU - Malmberg, Benjamin
AU  - Malmberg B
FAU - Liederman, Jacqueline
AU  - Liederman J
FAU - Papanicolaou, Andrew
AU  - Papanicolaou A
LA  - eng
GR  - K23 NS046565-04/NS/NINDS NIH HHS/United States
GR  - NS046565/NS/NINDS NIH HHS/United States
GR  - NS052505-03/NS/NINDS NIH HHS/United States
GR  - K23 NS046565/NS/NINDS NIH HHS/United States
GR  - K23 NS046565-02/NS/NINDS NIH HHS/United States
GR  - K23 NS046565-03/NS/NINDS NIH HHS/United States
GR  - K23 NS046565-01A2/NS/NINDS NIH HHS/United States
GR  - R01 NS052505/NS/NINDS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Anisotropy
MH  - Brain/pathology/physiopathology
MH  - Corpus Callosum/pathology/*physiopathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Dyslexia/pathology/*physiopathology
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Neural Pathways/pathology/*physiopathology
MH  - Neuropsychological Tests/statistics & numerical data
MH  - Psychomotor Performance/physiology
MH  - Reaction Time/physiology
MH  - *Reading
MH  - Vocabulary
PMC - PMC2667961
MID - NIHMS89980
EDAT- 2008/09/23 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/10/29
CRDT- 2008/09/23 09:00
PHST- 2008/09/23 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/23 09:00 [entrez]
PHST- 2009/10/29 00:00 [pmc-release]
AID - 10.1097/WNR.0b013e328314b8ee [doi]
PST - ppublish
SO  - Neuroreport. 2008 Oct 29;19(16):1627-31. doi: 10.1097/WNR.0b013e328314b8ee.