PMID- 18807266
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20181113
IS  - 0957-4530 (Print)
IS  - 0957-4530 (Linking)
VI  - 20
IP  - 1
DP  - 2009 Jan
TI  - Bioactive borosilicate glass scaffolds: improvement on the strength of 
      glass-based scaffolds for tissue engineering.
PG  - 365-72
LID - 10.1007/s10856-008-3582-3 [doi]
AB  - Three-dimensional macroporous scaffolds with the pore size of 200-500 mum were 
      fabricated by replication method using bioactive borosilicate glass from 
      Na(2)O-K(2)O-MgO-CaO-SiO(2)-P(2)O(5)-B(2)O(3) system. The effects of the strength 
      of the strut in reticulated scaffold, as well as the geometrical parameter of the 
      scaffold on the strength of reticulated scaffold were investigated. Scanning 
      electron microscope (SEM) and X-ray diffraction (XRD) results show that the 
      solidified glass struts in the reticulated scaffold could be obtained through a 
      sufficient vicious flow of glass, during the fabrication. By increasing the solid 
      content in slurries, from which the scaffold was made, the load-bearing units of 
      the reticulated scaffold switch from struts to the walls between the pores, and 
      the compressive strength dramatically climbs higher than the theoretical strength 
      calculated by Gibson model. In particular, the compressive strength of the 
      reticulated scaffold, as high as approximately 10 MPa with the porosity of 
      approximately 70%, is close to the reported compressive values of human 
      cancellous bone. This indicates the bioactive borosilicate glass-based scaffold 
      is a promising candidate for bone tissue engineering.
FAU - Liu, Xin
AU  - Liu X
AD  - Institute of Bioengineering and Information Technology Materials, Tongji 
      University, Shanghai, 200092, People's Republic of China.
FAU - Huang, Wenhai
AU  - Huang W
FAU - Fu, Hailuo
AU  - Fu H
FAU - Yao, Aihua
AU  - Yao A
FAU - Wang, Deping
AU  - Wang D
FAU - Pan, Haobo
AU  - Pan H
FAU - Lu, William W
AU  - Lu WW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080921
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Bioglass)
RN  - 0 (Bone Substitutes)
RN  - 0 (Silicates)
SB  - IM
MH  - Biomechanical Phenomena
MH  - Bone Substitutes/*chemistry
MH  - Ceramics/*chemistry
MH  - Compressive Strength
MH  - Humans
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Models, Theoretical
MH  - Silicates/*chemistry
MH  - Tissue Engineering
MH  - Tissue Scaffolds/*chemistry
MH  - X-Ray Diffraction
EDAT- 2008/09/23 09:00
MHDA- 2009/04/03 09:00
CRDT- 2008/09/23 09:00
PHST- 2008/05/23 00:00 [received]
PHST- 2008/08/29 00:00 [accepted]
PHST- 2008/09/23 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
PHST- 2008/09/23 09:00 [entrez]
AID - 10.1007/s10856-008-3582-3 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2009 Jan;20(1):365-72. doi: 10.1007/s10856-008-3582-3. 
      Epub 2008 Sep 21.