PMID- 18808425
OWN - NLM
STAT- MEDLINE
DCOM- 20090202
LR  - 20091111
IS  - 1469-8749 (Electronic)
IS  - 0012-1622 (Linking)
VI  - 50
IP  - 12
DP  - 2008 Dec
TI  - Mismatch negativity and frequency representational width in children with 
      specific language impairment.
PG  - 938-44
LID - 10.1111/j.1469-8749.2008.03093.x [doi]
AB  - The aim of this study was to compare the degree of frequency separation that is 
      required between tones to generate mismatch negativity (MMN) in a group of 
      children with specific language impairment (SLI) and a comparison group, who had 
      their temporal processing abilities assessed in a previous experiment. Using a 
      1000Hz standard (85%) and 1020, 1050, and 1100Hz deviant tones presented at 
      inter-stimulus intervals (ISIs) of 200 and 400ms, MMN was compared in 19 children 
      with SLI (13 males, six females, age range 7y 4mo-11y 10mo, mean age 9y 7mo [SD 
      1y 2mo]), and 19 comparison children (13 males, six females, age range 7y 3mo-11y 
      4mo, mean age 9y 5mo [SD 1y 3mo]). Temporal processing ability was assessed by 
      the Auditory Fusion Test-Revised. Children with SLI who had poor temporal 
      processing abilities generated a positive mismatch response (P-MMR) for 2% tone 
      contrasts at 400ms ISI but MMN with larger contrasts. These children also 
      generated stronger MMN than the comparison group at 200ms ISI for 2% contrasts. 
      Children with SLI who had good temporal processing abilities generated only P-MMR 
      in response to contrasts up to 10% for both ISIs. Some children with SLI show an 
      inverse relationship between frequency discrimination and temporal processing. 
      Furthermore, certain stimulus-related and biological criteria may need to be met 
      for P-MMR to switch to MMN.
FAU - Ahmmed, Ansar U
AU  - Ahmmed AU
AD  - Lancashire Teaching Hospitals NHS Trust, Preston, UK.
FAU - Clarke, Elaine M
AU  - Clarke EM
FAU - Adams, Catherine
AU  - Adams C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080919
PL  - England
TA  - Dev Med Child Neurol
JT  - Developmental medicine and child neurology
JID - 0006761
SB  - IM
MH  - Acoustic Stimulation
MH  - Attention/*physiology
MH  - Auditory Perceptual Disorders/diagnosis/physiopathology
MH  - Child
MH  - Contingent Negative Variation/*physiology
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Language Development Disorders/diagnosis/*physiopathology
MH  - Language Tests
MH  - Male
MH  - Pitch Discrimination/*physiology
MH  - Reference Values
MH  - Signal Processing, Computer-Assisted
MH  - Sound Spectrography
MH  - Time Perception/physiology
EDAT- 2008/09/24 09:00
MHDA- 2009/02/03 09:00
CRDT- 2008/09/24 09:00
PHST- 2008/09/24 09:00 [pubmed]
PHST- 2009/02/03 09:00 [medline]
PHST- 2008/09/24 09:00 [entrez]
AID - DMCN3093 [pii]
AID - 10.1111/j.1469-8749.2008.03093.x [doi]
PST - ppublish
SO  - Dev Med Child Neurol. 2008 Dec;50(12):938-44. doi: 
      10.1111/j.1469-8749.2008.03093.x. Epub 2008 Sep 19.