PMID- 18809331
OWN - NLM
STAT- MEDLINE
DCOM- 20090109
LR  - 20220408
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 33
IP  - 11
DP  - 2008 Nov
TI  - HIF-1 regulation: not so easy come, easy go.
PG  - 526-34
LID - 10.1016/j.tibs.2008.08.002 [doi]
AB  - The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular 
      response to hypoxia and its expression levels are tightly controlled through 
      synthesis and degradation. It is widely accepted that HIF-1alpha protein 
      accumulation during hypoxia results from inhibition of its oxygen-dependent 
      degradation by the von Hippel Lindau protein (pVHL) pathway. However, recent data 
      describe new pVHL- or oxygen-independent mechanisms for HIF-1alpha degradation. 
      Furthermore, the hypoxia-induced increase in HIF-1alpha levels is facilitated by 
      the continued translation of HIF-1alpha during hypoxia despite the global 
      inhibition of protein translation. Recent work has contributed to an increased 
      understanding of the mechanisms that control the translation and degradation of 
      HIF-1alpha under both normoxic and hypoxic conditions.
FAU - Yee Koh, Mei
AU  - Yee Koh M
AD  - Department of Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, TX 
      77030, USA.
FAU - Spivak-Kroizman, Taly R
AU  - Spivak-Kroizman TR
FAU - Powis, Garth
AU  - Powis G
LA  - eng
GR  - CA0179094/CA/NCI NIH HHS/United States
GR  - CA095060/CA/NCI NIH HHS/United States
GR  - CA109552/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20080921
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Receptors for Activated C Kinase)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Small Ubiquitin-Related Modifier Proteins)
RN  - 0 (USP20 protein, human)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - Animals
MH  - *Gene Expression Regulation/drug effects
MH  - Humans
MH  - Hypoxia/*physiopathology
MH  - Hypoxia-Inducible Factor 1/*genetics
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Protein Biosynthesis/physiology
MH  - Receptors for Activated C Kinase
MH  - Receptors, Cell Surface/metabolism
MH  - Small Ubiquitin-Related Modifier Proteins/metabolism
MH  - Ubiquitin Thiolesterase/metabolism
MH  - Von Hippel-Lindau Tumor Suppressor Protein/metabolism
RF  - 85
EDAT- 2008/09/24 09:00
MHDA- 2009/01/10 09:00
CRDT- 2008/09/24 09:00
PHST- 2008/06/16 00:00 [received]
PHST- 2008/08/19 00:00 [revised]
PHST- 2008/08/21 00:00 [accepted]
PHST- 2008/09/24 09:00 [pubmed]
PHST- 2009/01/10 09:00 [medline]
PHST- 2008/09/24 09:00 [entrez]
AID - S0968-0004(08)00187-4 [pii]
AID - 10.1016/j.tibs.2008.08.002 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2008 Nov;33(11):526-34. doi: 10.1016/j.tibs.2008.08.002. Epub 
      2008 Sep 21.