PMID- 18812013
OWN - NLM
STAT- MEDLINE
DCOM- 20090616
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 12
IP  - 2
DP  - 2009 Mar
TI  - S100B overexpressing mutant mice exhibit prolonged behavioural and biochemical 
      responses towards repeated intermittent binge treatments with MDMA.
PG  - 201-15
LID - 10.1017/S1461145708009437 [doi]
AB  - The recreational drug 3,4-methylenedioxy-metamphetamine (MDMA; 'ecstasy') 
      enhances serotonin and dopamine transmission. Repeated binge treatment with MDMA 
      (5 mg/kg, 3 times daily, 3 h apart, once per week for 4 wk) was found to increase 
      gene expression of S100B, a neurotrophic factor that modulates neuronal 
      plasticity. Mutant mice overexpressing S100B were investigated to better 
      understand how increased S100B expression may influence MDMA-induced biochemical 
      and behavioural responses. In open-field behaviour, the later MDMA binges 
      decreased rearing and thigmotaxis in S100B mutant mice compared to wild-type 
      mice. In the elevated plus-maze, MDMA increased open-arm entries in both 
      genotypes, but less tolerance to this effect was found in S100B mutant mice. 
      Serotonin transporter (SERT) density was up-regulated in the substantia nigra in 
      S100B mutant mice under baseline conditions. MDMA treatment increased SERT in 
      wild-type mice, but did not further increase it in S100B mutant mice. Dopamine 
      transporter density was down-regulated by MDMA in both genotypes in the striatum. 
      5-HT1B receptor density and G-protein coupling were higher in MDMA-treated S100B 
      mutant mice than in saline-treated mutant mice and MDMA-treated wild-type mice in 
      the medial globus pallidus. In conclusion, repeated MDMA treatment increases 
      S100B mRNA. Certain explorative and anxiolytic-like behaviours in response to 
      MDMA are potentiated and exhibit less tolerance in mice overexpressing S100B. The 
      genotype-dependent behavioural responses are paralleled by adaptations in the 
      serotonin system. Our data indicate that genetic differences in S100B gene 
      expression may predispose individual differences in the responsivity to repeated 
      intake of MDMA.
FAU - Kindlundh-Hogberg, Anna M S
AU  - Kindlundh-Hogberg AM
AD  - Section of Translational Neuropharmacology, Department of Physiology and 
      Pharmacology, Karolinska Institutet, Stockholm, Sweden. anna.kindlundh@fyfa.ki.se
FAU - Zhang, Xiaoqun
AU  - Zhang X
FAU - Svenningsson, Per
AU  - Svenningsson P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080924
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Hallucinogens)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Serotonin, 5-HT1B)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
RN  - 0 (S100b protein, mouse)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 37589-80-3 (Guanosine 5'-O-(3-Thiotriphosphate))
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Autoradiography/methods
MH  - Behavior, Animal/*drug effects/physiology
MH  - Brain/drug effects/metabolism
MH  - Brain Chemistry/*drug effects/genetics
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Drug Administration Schedule
MH  - Exploratory Behavior/drug effects/physiology
MH  - Gene Expression/genetics
MH  - Gene Expression Regulation/*drug effects/genetics
MH  - Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology
MH  - Hallucinogens/*administration & dosage
MH  - Locomotion/drug effects/genetics
MH  - Maze Learning/drug effects/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Nerve Growth Factors/*genetics/metabolism
MH  - Protein Binding/drug effects/genetics
MH  - RNA, Messenger/metabolism
MH  - Receptor, Serotonin, 5-HT1B/genetics/metabolism
MH  - S100 Calcium Binding Protein beta Subunit
MH  - S100 Proteins/*genetics/metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/metabolism
MH  - Time Factors
EDAT- 2008/09/25 09:00
MHDA- 2009/06/17 09:00
CRDT- 2008/09/25 09:00
PHST- 2008/09/25 09:00 [pubmed]
PHST- 2009/06/17 09:00 [medline]
PHST- 2008/09/25 09:00 [entrez]
AID - S1461145708009437 [pii]
AID - 10.1017/S1461145708009437 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2009 Mar;12(2):201-15. doi: 
      10.1017/S1461145708009437. Epub 2008 Sep 24.