PMID- 18813759
OWN - NLM
STAT- MEDLINE
DCOM- 20090415
LR  - 20190608
IS  - 0036-4665 (Print)
IS  - 0036-4665 (Linking)
VI  - 50
IP  - 4
DP  - 2008 Jul-Aug
TI  - Aids-related progressive multifocal leukoencephalopathy: a retrospective study in 
      a referral center in Sao Paulo, Brazil.
PG  - 209-12
LID - S0036-46652008000400004 [pii]
AB  - Few data are available about progressive multifocal leukoencephalopathy (PML) in 
      patients with acquired immunodeficiency syndrome (AIDS) from Brazil. The 
      objectives of this study were to describe the main features of patients with PML 
      and estimate its frequency among AIDS patients with central nervous system (CNS) 
      opportunistic diseases admitted to the Instituto de Infectologia Emilio Ribas, 
      Sao Paulo, Brazil, from April 2003 to April 2004. A retrospective and descriptive 
      study was performed. Twelve (6%) cases of PML were identified among 219 patients 
      with neurological diseases. The median age of patients with PML was 36 years and 
      nine (75%) were men. Nine (75%) patients were not on antiretroviral therapy at 
      admission. The most common clinical manifestations were: focal weakness (75%), 
      speech disturbances (58%), visual disturbances (42%), cognitive dysfunction 
      (42%), and impaired coordination (42%). The median CD4+ T-cell count was 45 
      cells/microL. Eight (67%) of 12 patients were laboratory-confirmed with PML and 
      four (33%) were possible cases. Eleven (92%) presented classic PML and only one 
      case had immune reconstitution inflammatory syndrome (IRIS)-related PML. In four 
      (33%) patients, PML was the first AIDS-defining illness. During hospitalization, 
      three patients (25%) died as a result of nosocomial pneumonia and nine (75%) were 
      discharged to home. Cases of PML were only exceeded by cases of cerebral 
      toxoplasmosis, cryptococcal meningoencephalitis, and CNS tuberculosis, the three 
      more frequent neurologic opportunistic infections in Brazil. The results of this 
      study suggest that PML is not an uncommon HIV-related neurologic disorder in a 
      referral center in Brazil.
FAU - Vidal, Jose E
AU  - Vidal JE
AD  - Departamento de Neurologia, Instituto de Infectologia Emilio Ribas, Sao Paulo, 
      SP, Brasil. josevibe@gmail.com
FAU - Penalva de Oliveira, Augusto C
AU  - Penalva de Oliveira AC
FAU - Fink, Maria Cristina D S
AU  - Fink MC
FAU - Pannuti, Claudio S
AU  - Pannuti CS
FAU - Trujillo, J Roberto
AU  - Trujillo JR
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Inst Med Trop Sao Paulo
JT  - Revista do Instituto de Medicina Tropical de Sao Paulo
JID - 7507484
SB  - IM
MH  - AIDS-Related Opportunistic Infections/diagnosis/*epidemiology
MH  - Adult
MH  - Brazil/epidemiology
MH  - Female
MH  - Humans
MH  - Leukoencephalopathy, Progressive Multifocal/diagnosis/*epidemiology/virology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2008/09/25 09:00
MHDA- 2009/04/16 09:00
CRDT- 2008/09/25 09:00
PHST- 2007/10/11 00:00 [received]
PHST- 2008/05/12 00:00 [accepted]
PHST- 2008/09/25 09:00 [pubmed]
PHST- 2009/04/16 09:00 [medline]
PHST- 2008/09/25 09:00 [entrez]
AID - S0036-46652008000400004 [pii]
AID - 10.1590/s0036-46652008000400004 [doi]
PST - ppublish
SO  - Rev Inst Med Trop Sao Paulo. 2008 Jul-Aug;50(4):209-12. doi: 
      10.1590/s0036-46652008000400004.