PMID- 18815107
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20091021
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 149
IP  - 40
DP  - 2008 Oct 5
TI  - [Reasons for proton-pump-inhibitor failure in the treatment of gastroesophageal 
      reflux disease].
PG  - 1881-8
LID - 10.1556/OH.2008.28438 [doi]
AB  - The introduction of proton pump inhibitors (PPI) has facilitated the successful 
      management of patients with gastroesophageal reflux disease (GERD). In a minor, 
      but still relevant proportion of patients with GERD-like symptoms, PPI therapy 
      has also proved to be ineffective. In such cases, the first question to be 
      answered is if the symptoms and complaints are related to GERD indeed, or another 
      disorder should be searched for. If GERD is still the most likely diagnosis, 
      patients' compliance should be thoroughly investigated before any further 
      diagnostic and therapeutic measure is taken. If PPI failure is not a result of 
      inadequate management of GERD, there are several other disorders to be ruled out. 
      In our review, we summarize the most important differential diagnostic issues of 
      PPI failure.
FAU - Juhasz, Mark
AU  - Juhasz M
AD  - Semmelweis Egyetem, Altalanos Orvostudomanyi Kar II, Belgyogyaszati Klinika, 
      Budapest, Szentkiralyi u. 46, 1088. juhaszmarkdr@freemail.hu
FAU - Tulassay, Zsolt
AU  - Tulassay Z
LA  - hun
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - A protonpumpagatlo kezeles eredmenytelensegenek okai gastrooesophagealis 
      refluxbetegsegben.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Biological Availability
MH  - Diagnosis, Differential
MH  - Gastroesophageal Reflux/*diagnosis/*drug therapy/metabolism/physiopathology
MH  - Humans
MH  - Proton Pump Inhibitors/pharmacokinetics/*therapeutic use
MH  - Treatment Failure
RF  - 54
EDAT- 2008/09/26 09:00
MHDA- 2008/11/14 09:00
CRDT- 2008/09/26 09:00
PHST- 2008/09/26 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/09/26 09:00 [entrez]
AID - 5864H663J801H3X2 [pii]
AID - 10.1556/OH.2008.28438 [doi]
PST - ppublish
SO  - Orv Hetil. 2008 Oct 5;149(40):1881-8. doi: 10.1556/OH.2008.28438.