PMID- 18817832
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20220331
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 69
IP  - 11
DP  - 2008 Nov
TI  - HLA-G-dependent suppressor cells: Diverse by nature, function, and significance.
PG  - 700-7
LID - 10.1016/j.humimm.2008.08.280 [doi]
AB  - Regulatory cells play a crucial role in the maintenance of the immune homeostasis 
      and in pathologic conditions such as those involving transplantations, autoimmune 
      diseases, infections, and cancers. The regulatory cells block the function of 
      other effector cells and can induce the formation of other regulatory cells. 
      Human leukocyte antigen (HLA)-G is a nonclassic class I molecule that functions 
      as an immune-tolerogenic molecule with restricted tissue expression. Numerous 
      studies have highlighted the role of HLA-G in the context of transplantation, 
      cancer, autoimmunity, and hematologic diseases. HLA-G has a direct inhibitory 
      effect on immune responses but there is increasing evidence that it also has a 
      long term immunomodulatory effect and can induce the generation of 
      suppressor/regulatory cells. In this article we review the different natures, 
      functions, and significance of the various types of HLA-G-dependent suppressor 
      cells.
FAU - Carosella, Edgardo D
AU  - Carosella ED
AD  - CEA, I2BM, Service de Recherches en Hemato-Immunologie, Institut Universitaire 
      d'Hematologie, Hopital Saint Louis, Paris, France.
FAU - HoWangYin, Kiave-Yune
AU  - HoWangYin KY
FAU - Favier, Benoit
AU  - Favier B
FAU - LeMaoult, Joel
AU  - LeMaoult J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080924
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Autoimmune Diseases/immunology
MH  - HLA Antigens/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Homeostasis/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Infections/immunology
MH  - Neoplasms/immunology
MH  - Transplantation Immunology
RF  - 79
EDAT- 2008/09/27 09:00
MHDA- 2009/01/24 09:00
CRDT- 2008/09/27 09:00
PHST- 2008/06/24 00:00 [received]
PHST- 2008/08/01 00:00 [revised]
PHST- 2008/08/12 00:00 [accepted]
PHST- 2008/09/27 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
PHST- 2008/09/27 09:00 [entrez]
AID - S0198-8859(08)00440-0 [pii]
AID - 10.1016/j.humimm.2008.08.280 [doi]
PST - ppublish
SO  - Hum Immunol. 2008 Nov;69(11):700-7. doi: 10.1016/j.humimm.2008.08.280. Epub 2008 
      Sep 24.