PMID- 18818386
OWN - NLM
STAT- MEDLINE
DCOM- 20081204
LR  - 20220330
IS  - 8750-7587 (Print)
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 105
IP  - 5
DP  - 2008 Nov
TI  - Effects of physical activity on strength and skeletal muscle fat infiltration in 
      older adults: a randomized controlled trial.
PG  - 1498-503
LID - 10.1152/japplphysiol.90425.2008 [doi]
AB  - Considerable evidence suggests that the loss of strength and muscle mass appear 
      to be inevitable consequences of aging. Moreover, aging is associated with an 
      increase in body fat. This study examined whether increased physical activity 
      could prevent or reverse the losses of strength and skeletal muscle mass as well 
      as the gain in fat in older adults. Eleven men and 31 women completed a 
      randomized trial consisting of either a physical activity (PA; n = 22) or 
      successful aging health educational control (SA; n = 20) group. Isokinetic knee 
      extensor strength and computed tomography-derived midthigh skeletal muscle and 
      adipose tissue cross-sectional areas (CSA) were assessed at baseline and at 12 mo 
      following randomization. Total body weight and muscle CSA decreased in both 
      groups, but these losses were not different between groups. Strength adjusted for 
      muscle mass decreased (-20.1 +/- 9.3%, P < 0.05) in SA. The loss of strength was 
      completely prevented in PA (+2.5 +/- 8.3%). In addition, there was a significant 
      increase (18.4 +/- 6.0%) in muscle fat infiltration in SA, but this gain was 
      nearly completely prevented in PA (2.3 +/- 5.7%). In conclusion, regular physical 
      activity prevents both the age-associated loss of muscle strength and increase in 
      muscle fat infiltration in older adults with moderate functional limitations.
FAU - Goodpaster, Bret H
AU  - Goodpaster BH
AD  - Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. 
      bgood@pitt.edu
FAU - Chomentowski, Peter
AU  - Chomentowski P
FAU - Ward, Bryan K
AU  - Ward BK
FAU - Rossi, Andrea
AU  - Rossi A
FAU - Glynn, Nancy W
AU  - Glynn NW
FAU - Delmonico, Matthew J
AU  - Delmonico MJ
FAU - Kritchevsky, Stephen B
AU  - Kritchevsky SB
FAU - Pahor, Marco
AU  - Pahor M
FAU - Newman, Anne B
AU  - Newman AB
LA  - eng
GR  - UL1 RR029890/RR/NCRR NIH HHS/United States
GR  - UL1 TR000064/TR/NCATS NIH HHS/United States
GR  - P30 AG028740/AG/NIA NIH HHS/United States
GR  - U01-AG-022376/AG/NIA NIH HHS/United States
GR  - U01 AG022376/AG/NIA NIH HHS/United States
GR  - P30 AG021332/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20080925
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
MH  - *Adiposity
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - *Muscle Strength
MH  - Muscle, Skeletal/diagnostic imaging/*physiopathology
MH  - Muscular Diseases/diagnostic imaging/physiopathology/*therapy
MH  - Time Factors
MH  - Tomography, X-Ray Computed
PMC - PMC2584841
EDAT- 2008/09/27 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/11/01
CRDT- 2008/09/27 09:00
PHST- 2008/09/27 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/09/27 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - 90425.2008 [pii]
AID - JAPPL-90425-2008 [pii]
AID - 10.1152/japplphysiol.90425.2008 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2008 Nov;105(5):1498-503. doi: 
      10.1152/japplphysiol.90425.2008. Epub 2008 Sep 25.