PMID- 18820586
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20090512
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 27
IP  - 10 Suppl
DP  - 2008 Oct
TI  - Lung dendritic cells in respiratory syncytial virus bronchiolitis.
PG  - S89-91
LID - 10.1097/INF.0b013e318168b6f0 [doi]
AB  - Respiratory syncytial virus (RSV) bronchiolitis, an important respiratory disease 
      in infancy, is thought to be caused by severe inflammation of the small 
      peripheral airways and has been associated with the development of recurrent 
      wheeze, childhood asthma, and early allergen sensitization. Both innate and 
      adaptive immune responses are thought to contribute to the development of 
      bronchiolitis in RSV infection. If vaccination and specific therapy for 
      bronchiolitis, which are currently lacking, are to be developed, detailed 
      understanding of the immune responses involved is essential. Dendritic cells 
      (DCs) are uniquely positioned to link innate to adaptive immune responses and may 
      therefore be central to the development of bronchiolitis. In murine models, 
      plasmacytoid DCs are recruited to the lung early in infection, presumably from 
      the bone marrow, whereas lung myeloid DCs increase in numbers later in infection, 
      with the advent of inflammation, and are derived from local lung precursors. 
      Plasmacytoid DCs limit viral replication and they may have additional regulatory 
      properties controlling pulmonary inflammation and lung function changes during 
      bronchiolitis. In contrast, lung myeloid DCs are likely to contribute to 
      inflammation during and after bronchiolitis and they may also facilitate 
      sensitization to allergens. Myeloid DCs mature upon RSV infection and become 
      potent activators of naive T cells, whereas in healthy lungs they are mostly 
      immature and unable to stimulate naive T cells. As central players in the 
      induction of adaptive immune responses, lung DCs need to be considered as targets 
      for novel therapies and vaccination approaches.
FAU - Schwarze, Jurgen
AU  - Schwarze J
AD  - Child Life and Health and Centre for Inflammation Research, University of 
      Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK. 
      jurgen.schwarze@ed.ac.uk
LA  - eng
GR  - 067454/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Cytokines)
SB  - IM
CIN - Pediatr Infect Dis J. 2009 May;28(5):450; author reply 450-1. PMID: 19295459
MH  - Animals
MH  - Bronchiolitis, Viral/*immunology
MH  - Child, Preschool
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Lung/*immunology/virology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Respiratory Syncytial Viruses/*immunology/physiology
MH  - T-Lymphocytes/immunology
MH  - Virus Replication
EDAT- 2008/10/23 09:00
MHDA- 2008/11/19 09:00
CRDT- 2008/10/23 09:00
PHST- 2008/10/23 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/10/23 09:00 [entrez]
AID - 00006454-200810001-00011 [pii]
AID - 10.1097/INF.0b013e318168b6f0 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2008 Oct;27(10 Suppl):S89-91. doi: 
      10.1097/INF.0b013e318168b6f0.