PMID- 18821292
OWN - NLM
STAT- MEDLINE
DCOM- 20100223
LR  - 20151119
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 129
IP  - 7
DP  - 2009 Jul
TI  - Preliminary study of proteomic shift from normal to premalignant laryngeal 
      lesions and to laryngeal squamous cell carcinoma.
PG  - 774-8
LID - 10.1080/00016480802412797 [doi]
AB  - CONCLUSIONS: The malignant shift was discovered to begin even in the premalignant 
      stage in the comparison of premalignant laryngeal lesions (PMLLs) with laryngeal 
      squamous cell carcinoma (LSCC) and healthy controls. The differential expression 
      of proteins among normal, PMLL, and cancer cells might provide the prediction for 
      the changes from normal to PMLL and to malignant disease. OBJECTIVES: To study 
      the serum proteomic shift from normal control to PMLL and progression to LSCC. 
      MATERIALS AND METHODS: A total of 211 serum samples from patients with LSCC (n = 
      89 at stage I-II) or PMLL (n = 57), or normal controls (n = 65) were obtained 
      with informed consent. Serum protein profiles on weak cationic exchange (WCX2) 
      were performed by surface-enhanced laser desorption/ionization mass spectrometry 
      (SELDI-TOF MS) and then analyzed by Biomarker Wizard software. RESULTS: Peak 
      intensities of serum from PMLLs were compared to normal controls and serum from 
      patients with LSCC. Mean intensity differed significantly only for one peak (4532 
      Da, p = 0.032) between LSCC and precancerous diseases, while 13 peaks differed 
      significantly between precancerous diseases and normal controls. Eighteen 
      biomarkers were selected to separate stage I- II LSCC patients and healthy 
      controls.
FAU - Cheng, Lei
AU  - Cheng L
AD  - Department of Otolaryngology-Head and Neck Surgery, Fudan University Affiliated 
      Eye, Ear, Nose and Throat Hospital, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
FAU - Tao, Lei
AU  - Tao L
FAU - Zhang, Ming
AU  - Zhang M
FAU - Cui, Jiefeng
AU  - Cui J
FAU - Liu, Yinkun
AU  - Liu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Blood Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Blood Proteins/*analysis
MH  - *Cell Transformation, Neoplastic/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnosis/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Precancerous Conditions/*diagnosis/pathology
MH  - Predictive Value of Tests
MH  - Proteomics/*methods
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
EDAT- 2008/09/30 09:00
MHDA- 2010/02/24 06:00
CRDT- 2008/09/30 09:00
PHST- 2008/09/30 09:00 [pubmed]
PHST- 2010/02/24 06:00 [medline]
PHST- 2008/09/30 09:00 [entrez]
AID - 903099639 [pii]
AID - 10.1080/00016480802412797 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2009 Jul;129(7):774-8. doi: 10.1080/00016480802412797.