PMID- 18821596
OWN - NLM
STAT- MEDLINE
DCOM- 20090602
LR  - 20180913
IS  - 1536-4844 (Electronic)
IS  - 1078-0998 (Linking)
VI  - 15
IP  - 3
DP  - 2009 Mar
TI  - Intestinal dendritic cells and epithelial barrier dysfunction in Crohn's disease.
PG  - 436-53
LID - 10.1002/ibd.20660 [doi]
AB  - Crohn's disease (CD) is a chronic gastrointestinal inflammatory disorder 
      considered to be the result of an inappropriate and exaggerated mucosal immune 
      reaction to yet undefined triggers from the gut flora in genetically predisposed 
      individuals. This inflammatory phenomenon has been characterized by an adaptive 
      T-cell response in addition to an abnormal function of the innate immune system. 
      Dendritic cells (DCs) are constituents of this innate system, inducing T-cell 
      activation via antigen presentation. In the gut, mucosal DCs are separated from 
      the luminal milieu by a monolayer of cylindrical epithelial cells that forms an 
      anatomical and physiological barrier that controls the normal traffic of antigens 
      between both compartments. An imbalance of colonic and ileal DC distribution in 
      tissues from CD patients as well as functional differences between DCs isolated 
      from normal and diseased intestinal samples have been demonstrated. Moreover, a 
      gut barrier defect in the para- and transepithelial routes in addition to a 
      significant reduction in the intestinal secretion of epithelial products involved 
      in barrier function has been well documented in CD. Therefore, this may expose 
      the diseased mucosa to overwhelming amounts of antigens, resulting in abnormal DC 
      activation and a subsequent imbalance in their distribution. In conclusion, this 
      review provides a summary of relevant progress in CD, intestinal epithelial 
      permeability, and DCs highlighting a potential relationship between increased 
      epithelial permeability and abnormal DC distribution during the pathogenesis of 
      intestinal inflammation.
FAU - Silva, Manuel A
AU  - Silva MA
AD  - Department of Pathology and Molecular Medicine, Intestinal Disease Research 
      Programme, McMaster University, Hamilton, Ontario, Canada. msilvamu@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
SB  - IM
MH  - Animals
MH  - Cell Membrane Permeability/*physiology
MH  - Crohn Disease/immunology/*metabolism/pathology
MH  - Dendritic Cells/metabolism/*pathology
MH  - Humans
MH  - Immunity, Cellular/*immunology
RF  - 190
EDAT- 2008/09/30 09:00
MHDA- 2009/06/03 09:00
CRDT- 2008/09/30 09:00
PHST- 2008/09/30 09:00 [pubmed]
PHST- 2009/06/03 09:00 [medline]
PHST- 2008/09/30 09:00 [entrez]
AID - 10.1002/ibd.20660 [doi]
PST - ppublish
SO  - Inflamm Bowel Dis. 2009 Mar;15(3):436-53. doi: 10.1002/ibd.20660.