PMID- 18824448
OWN - NLM
STAT- MEDLINE
DCOM- 20081125
LR  - 20081212
IS  - 1525-7304 (Print)
IS  - 1525-7304 (Linking)
VI  - 9
IP  - 5
DP  - 2008 Sep
TI  - Primary pleuropulmonary synovial sarcoma.
PG  - 257-61
LID - 10.3816/CLC.2008.n.040 [doi]
AB  - Pleuropulmonary synovial sarcoma (PPSS) is increasingly recognized as a subtype 
      of sarcoma because of the recent identification of a distinctive chromosomal 
      translocation specific to synovial sarcoma. Soft-tissue synovial sarcoma is far 
      more common than PPSS and typically develops in para-articular locations of the 
      extremities, affects young and middle-aged adults, with no difference in 
      distribution between the sexes, and has well-documented radiologic 
      manifestations. Pleuropulmonary synovial sarcoma can arise in the chest wall, 
      heart, mediastinum, pleura, or lung, and it shares patient demographics and 
      several imaging features with its soft-tissue counterpart. Patients present with 
      a cough, chest pain, or dyspnea. On chest radiographs, PPSS typically appears as 
      a sharply marginated mass with uniform opacity, based in the pleura or in the 
      lung, and often accompanied by an ipsilateral pleural effusion. Computed 
      tomographic images show a well-circumscribed, heterogeneously enhanced lesion 
      without associated involvement of bone and without calcifications (except in the 
      case of a chest wall primary tumor). Magnetic resonance imaging provides superior 
      demonstration of nodular soft tissue and multilocular fluid-filled internal 
      components of PPSS, in addition to peripheral rim enhancement after the 
      intravenous administration of a gadoliniumbased contrast material such as 
      gadopentetate dimeglumine. Current treatment consists of surgical resection 
      followed by chemotherapy, radiation therapy, or both.
FAU - Mirzoyan, Michael
AU  - Mirzoyan M
AD  - Department of Medicine, Fairview Hospital, Cleveland, OH 44111, USA.
FAU - Muslimani, Ala'a
AU  - Muslimani A
FAU - Setrakian, Sebouh
AU  - Setrakian S
FAU - Swedeh, Mohamed
AU  - Swedeh M
FAU - Daw, Hamed A
AU  - Daw HA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Lung Cancer
JT  - Clinical lung cancer
JID - 100893225
SB  - IM
MH  - Humans
MH  - Lung Neoplasms/*pathology/therapy
MH  - Pleural Neoplasms/*pathology/therapy
MH  - Sarcoma, Synovial/*pathology/therapy
RF  - 51
EDAT- 2008/10/01 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/10/01 09:00
PHST- 2008/10/01 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/01 09:00 [entrez]
AID - S1525-7304(11)70850-6 [pii]
AID - 10.3816/CLC.2008.n.040 [doi]
PST - ppublish
SO  - Clin Lung Cancer. 2008 Sep;9(5):257-61. doi: 10.3816/CLC.2008.n.040.