PMID- 18825156
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20220311
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 32
IP  - 12
DP  - 2008 Dec
TI  - Negative association between plasma levels of adiponectin and polychlorinated 
      biphenyl 153 in obese women under non-energy-restrictive regime.
PG  - 1875-8
LID - 10.1038/ijo.2008.169 [doi]
AB  - The aim of this study was to reveal whether accumulation of the persistent 
      organic pollutants (POPs), especially polychlorinated biphenyl 
      (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of 
      adiponectin in obese patients. The study was designed as a longitudinal 
      intervention trial with a control group, where 27 obese women (body mass index 
      (BMI)>30 kg/m(2); age 21-74 years) were studied before (OB) and after (OB-LCD) a 
      3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 
      female volunteers without LCD intervention were used (C; BMI=19-25 kg/m(2); age 
      21-64 years). Plasma levels of PCB 153 were measured by high-resolution gas 
      chromatography with electron capture detection; total adiponectin and insulin 
      plasma levels were quantified by immunoassays; and adiponectin multimeric 
      complexes were quantified by immunoblotting. Plasma levels of total adiponectin, 
      high and medium molecular weight multimers significantly negatively correlated 
      with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD 
      intervention lowered BMI by 3.3+/-3.0 kg/m(2). Our results may suggest 
      suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive 
      regime, which may contribute to the known association of PCB 153 and other POPs 
      with type 2 diabetes.
FAU - Mullerova, D
AU  - Mullerova D
AD  - 1st Medical Department, Charles University Medical School and Teaching Hospital 
      at Plzen, Plzen, Czech Republic. dana.mullerova@lfp.cuni.cz
FAU - Kopecky, J
AU  - Kopecky J
FAU - Matejkova, D
AU  - Matejkova D
FAU - Muller, L
AU  - Muller L
FAU - Rosmus, J
AU  - Rosmus J
FAU - Racek, J
AU  - Racek J
FAU - Sefrna, F
AU  - Sefrna F
FAU - Opatrna, S
AU  - Opatrna S
FAU - Kuda, O
AU  - Kuda O
FAU - Matejovic, M
AU  - Matejovic M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080930
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Insulin)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Caloric Restriction
MH  - Case-Control Studies
MH  - Czech Republic
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Young Adult
EDAT- 2008/10/01 09:00
MHDA- 2009/09/22 06:00
CRDT- 2008/10/01 09:00
PHST- 2008/10/01 09:00 [entrez]
PHST- 2008/10/01 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - ijo2008169 [pii]
AID - 10.1038/ijo.2008.169 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2008 Dec;32(12):1875-8. doi: 10.1038/ijo.2008.169. Epub 2008 
      Sep 30.