PMID- 18826096
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20221207
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 43
IP  - 6
DP  - 2008 Jun
TI  - [Association between genetic polymorphisms in methylenetetrahydrofolate reductase 
      and risk of laryngeal squamous cell carcinoma].
PG  - 435-8
AB  - OBJECTIVE: To determine whether genetic variations in methylenetetrahydrofolate 
      reductase (MTHFR) are associated with the risk of laryngeal squamous cell 
      carcinoma (LSCC) in a Chinese population. METHODS: Two hundred and seven cases 
      with LSCC and 400 matched health controls were genotyped for the MTHFR 677C > T 
      and 1298A > C polymorphisms by PCR-restriction fragment length polymorphism 
      (PCR-RFLP) methods. The relation between these genotypes and risk of LSCC and 
      gene-environment interaction were analyzed. The adjusted odds ratios (OR) and 95% 
      confidence intervals (CI) were calculated by using unconditional Logistic 
      regression model. RESULTS: The individuals with 677CT and 677TT genotype had a 
      1.66-fold (95% CI 1.08-2.52) and 3.35-fold (95% CI 2.07-5.54) increased risk of 
      developing LSCC compared with those who had 677CC genotype. The individuals with 
      MTHFR 1298A > C genotype was not significantly different between the two groups. 
      Furthermore, cigarette smoking was also found to interact with MTHFR 677C > T 
      polymorphism in increasing the risk to LCSS further demonstrating the role of 
      gene-environment interaction in development of LSCC. CONCLUSIONS: These findings 
      suggested that the MTHFR 677C > T polymorphism may contribute to the risk of 
      developing LSCC among Chinese population.
FAU - Ni, Xin
AU  - Ni X
AD  - Department of Otolaryngology Head and Neck Surgery, Affiliated Beijing Tongren 
      Hospital, Capital University of Medical Sciences, Key Laboratory of 
      Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing 100730, 
      China.
FAU - Tai, Jun
AU  - Tai J
FAU - Ma, Li-Jing
AU  - Ma LJ
FAU - Huang, Zhi-Gang
AU  - Huang ZG
FAU - Fang, Ju-Gao
AU  - Fang JG
FAU - Chen, Xiao-Hong
AU  - Chen XH
FAU - Zhang, Wei
AU  - Zhang W
FAU - Zhao, Li-Ping
AU  - Zhao LP
FAU - Lu, Xin-Xin
AU  - Lu XX
FAU - Han, De-Min
AU  - Han DM
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Aged
MH  - Asian People
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2008/10/02 09:00
MHDA- 2011/03/22 06:00
CRDT- 2008/10/02 09:00
PHST- 2008/10/02 09:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
PHST- 2008/10/02 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Jun;43(6):435-8.