PMID- 18827064
OWN - NLM
STAT- MEDLINE
DCOM- 20090105
LR  - 20161124
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 159
IP  - 6
DP  - 2008 Dec
TI  - The appearance of the adrenal glands on computed tomography in multiple endocrine 
      neoplasia type 1.
PG  - 819-24
LID - 10.1530/EJE-08-0516 [doi]
AB  - AIMS: To review the morphology of the adrenal glands in multiple endocrine 
      neoplasia type 1 (MEN1) on computed tomography (CT) to compare the results with 
      established normal values for adrenal size and nodularity and to correlate 
      adrenal size with serum cortisol secretory dynamics. MATERIALS AND METHODS: Two 
      observers independently reviewed the adrenal CT in 28 patients with MEN1, 
      measuring the maximum width of the body of the gland and the medial and lateral 
      limbs. Incidence and location of nodules >5 mm within the gland were recorded. 
      Following exclusion of known cases of Cushing's syndrome, adrenal gland size was 
      compared with previously documented normative data. Adrenal gland size was 
      compared between patients with normal and abnormal cortisol dynamics. RESULTS: 
      Comparison of mean adrenal size in MEN1 patients with normative data showed that 
      the adrenal limbs were significantly larger in MEN1 than normal (P<0.0001 in all 
      four limbs). Adrenal body was also significantly larger (P<0.05). Nodules were 
      demonstrated in 17 (60%) of patients (versus 0.4-2% in the normal population). No 
      statistically significant correlation was demonstrated between adrenal limb 
      hyperplasia and abnormal cortisol dynamics. CONCLUSIONS: In patients with MEN1, 
      adrenal limb hyperplasia and adrenal nodules are significantly more common than 
      in the normal population, a phenomenon not previously documented in a 
      quantitative manner. There was no significant correlation between adrenal limb 
      hyperplasia and abnormal cortisol dynamics.
FAU - Whitley, S A
AU  - Whitley SA
AD  - Department of Diagnostic Imaging, St Bartholomew's Hospital, Barts and the London 
      NHS Trust and QMUL, London, UK.
FAU - Moyes, V J
AU  - Moyes VJ
FAU - Park, K M
AU  - Park KM
FAU - Brooke, A M
AU  - Brooke AM
FAU - Grossman, A B
AU  - Grossman AB
FAU - Chew, S L
AU  - Chew SL
FAU - Rockall, A G
AU  - Rockall AG
FAU - Monson, J P
AU  - Monson JP
FAU - Reznek, R H
AU  - Reznek RH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080930
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenal Glands/*diagnostic imaging/drug effects
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Dexamethasone/administration & dosage
MH  - Female
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/blood/*diagnostic imaging/drug therapy
MH  - Retrospective Studies
MH  - *Tomography, X-Ray Computed/methods
EDAT- 2008/10/02 09:00
MHDA- 2009/01/06 09:00
CRDT- 2008/10/02 09:00
PHST- 2008/10/02 09:00 [pubmed]
PHST- 2009/01/06 09:00 [medline]
PHST- 2008/10/02 09:00 [entrez]
AID - EJE-08-0516 [pii]
AID - 10.1530/EJE-08-0516 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2008 Dec;159(6):819-24. doi: 10.1530/EJE-08-0516. Epub 2008 Sep 
      30.