PMID- 18827366
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 31
IP  - 10
DP  - 2008 Oct
TI  - Histamine release inhibitory activity of Piper nigrum leaf.
PG  - 1973-6
AB  - Oral administration of a methanolic extract of Piper nigrum leaf (PN-ext, 50, 200 
      and 500 mg/kg) showed a potent dose-dependent inhibition of dinitrofluorobenzene 
      (DNFB)-induced cutaneous reaction at 1 h [immediate phase response (IPR)] after 
      and 24 h [late phase response (LPR)] after DNFB challenge in mice which were 
      passively sensitized with anti-dinitrophenyl (DNP) IgE antibody. Ear swelling 
      inhibitory effect of PN-ext (50, 200 and 500 mg/kg, per os (p.o.)) on very late 
      phase response (vLPR) in the model mice was significant but weaker than that on 
      IPR. Oral administration of PN-ext (50, 200 and 500 mg/kg for 7 d) inhibited 
      picryl chloride (PC)-induced ear swelling in PC sensitized mice. PN-ext exhibited 
      in vitro inhibitory effect on compound 48/80-induced histamine release from rat 
      peritoneal mast cells. Two lignans of PN-ext, (-)-cubebin (1) and 
      (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), were identified as major 
      active principles having histamine release inhibitory activity.
FAU - Hirata, Noriko
AU  - Hirata N
AD  - School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 
      577-8502, Japan.
FAU - Naruto, Shunsuke
AU  - Naruto S
FAU - Inaba, Kazunori
AU  - Inaba K
FAU - Itoh, Kimihisa
AU  - Itoh K
FAU - Tokunaga, Masashi
AU  - Tokunaga M
FAU - Iinuma, Munekazu
AU  - Iinuma M
FAU - Matsuda, Hideaki
AU  - Matsuda H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (3,4-dimethoxy-3,4-desmethylenedioxycubebin)
RN  - 0 (Lignans)
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - J237078S8A (cubebin)
RN  - Z4ZG7O5SZ9 (Picryl Chloride)
SB  - IM
MH  - Animals
MH  - Dermatitis, Contact/prevention & control
MH  - Female
MH  - Histamine Release/*drug effects
MH  - Hypersensitivity, Immediate/prevention & control
MH  - Lignans/isolation & purification/pharmacology
MH  - Mast Cells/drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Picryl Chloride
MH  - Piper nigrum/*chemistry
MH  - Plant Extracts/chemistry/pharmacology
MH  - Plant Leaves/chemistry
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2008/10/02 09:00
MHDA- 2008/11/18 09:00
CRDT- 2008/10/02 09:00
PHST- 2008/10/02 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/10/02 09:00 [entrez]
AID - JST.JSTAGE/bpb/31.1973 [pii]
AID - 10.1248/bpb.31.1973 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2008 Oct;31(10):1973-6. doi: 10.1248/bpb.31.1973.