PMID- 18827882
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20181113
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 2
IP  - 10
DP  - 2008 Oct 1
TI  - Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe 
      forms of dengue virus infection, dengue hemorrhagic fever and dengue shock 
      syndrome.
PG  - e304
LID - 10.1371/journal.pntd.0000304 [doi]
LID - e304
AB  - BACKGROUND: Dengue virus (DV) infection is one of the most important 
      mosquito-borne diseases in the tropics. Recently, the severe forms, dengue 
      hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading 
      cause of death among children in Southern Vietnam. Protective and/or pathogenic T 
      cell immunity is supposed to be important in the pathogenesis of DHF and DSS. 
      METHODOLOGY/PRINCIPAL FINDINGS: To identify HLA alleles controlling T cell 
      immunity against dengue virus (DV), we performed a hospital-based case control 
      study at Children's Hospital No.2, Ho Chi Minh City (HCMC), and Vinh Long 
      Province Hospital (VL) in Southern Vietnam from 2002 to 2005. A total of 211 and 
      418 patients with DHF and DSS, respectively, diagnosed according to the World 
      Health Organization (WHO) criteria, were analyzed for their characteristic HLA-A, 
      -B and -DRB1 alleles. Four hundred fifty healthy children (250 from HCMC and 200 
      from VL) of the same Kinh ethnicity were also analyzed as population background. 
      In HLA class I, frequency of the HLA-A*24 showed increased tendency in both DHF 
      and DSS patients, which reproduced a previous study. The frequency of A*24 with 
      histidine at codon 70 (A*2402/03/10), based on main anchor binding site 
      specificity analysis in DSS and DHF patients, was significantly higher than that 
      in the population background groups (HCMC 02-03 DSS: OR = 1.89, P = 0.008, DHF: 
      OR = 1.75, P = 0.033; VL 02-03 DSS: OR = 1.70, P = 0.03, DHF: OR = 1.46, P = 
      0.38; VL 04-05 DSS: OR = 2.09, P = 0.0075, DHF: OR = 2.02, P = 0.038). In HLA 
      class II, the HLA-DRB1*0901 frequency was significantly decreased in secondary 
      infection of DSS in VL 04-05 (OR = 0.35, P = 0.0025, Pc = 0.03). Moreover, the 
      frequency of HLA-DRB1*0901 in particular was significantly decreased in DSS when 
      compared with DHF in DEN-2 infection (P = 0.02). CONCLUSION: This study improves 
      our understanding of the risk of HLA-class I for severe outcome of DV infection 
      in the light of peptide anchor binding site and provides novel evidence that 
      HLA-class II may control disease severity (DHF to DSS) in DV infection.
FAU - Nguyen, Thi Phuong Lan
AU  - Nguyen TP
AD  - Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki 
      University, Japan.
FAU - Kikuchi, Mihoko
AU  - Kikuchi M
FAU - Vu, Thi Que Huong
AU  - Vu TQ
FAU - Do, Quang Ha
AU  - Do QH
FAU - Tran, Thi Thuy
AU  - Tran TT
FAU - Vo, Dinh Tham
AU  - Vo DT
FAU - Ha, Manh Tuan
AU  - Ha MT
FAU - Vo, Van Tuong
AU  - Vo VT
FAU - Cao, Thi Phi Nga
AU  - Cao TP
FAU - Tran, Van Dat
AU  - Tran VD
FAU - Oyama, Toshifumi
AU  - Oyama T
FAU - Morita, Kouichi
AU  - Morita K
FAU - Yasunami, Michio
AU  - Yasunami M
FAU - Hirayama, Kenji
AU  - Hirayama K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081001
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dengue Virus/isolation & purification/physiology
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infant
MH  - Male
MH  - Severe Dengue/*genetics/*immunology/virology
PMC - PMC2553281
COIS- The authors have declared that no competing interests exist.
EDAT- 2008/10/02 09:00
MHDA- 2010/03/17 06:00
PMCR- 2008/10/01
CRDT- 2008/10/02 09:00
PHST- 2007/12/18 00:00 [received]
PHST- 2008/08/29 00:00 [accepted]
PHST- 2008/10/02 09:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
PHST- 2008/10/02 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - 07-PNTD-RA-0331R2 [pii]
AID - 10.1371/journal.pntd.0000304 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2008 Oct 1;2(10):e304. doi: 10.1371/journal.pntd.0000304.