PMID- 18829021
OWN - NLM
STAT- MEDLINE
DCOM- 20090923
LR  - 20220311
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 92
IP  - 3
DP  - 2009 Sep
TI  - Preimplantation aneuploid embryos undergo self-correction in correlation with 
      their developmental potential.
PG  - 890-896
LID - S0015-0282(08)03284-6 [pii]
LID - 10.1016/j.fertnstert.2008.07.1761 [doi]
AB  - OBJECTIVE: To investigate the incidence of embryos' self-correction during 
      preimplantation development in terms of mosaicism and in correlation with its 
      developmental stage. DESIGN: Prospective study to compare the chromosome status 
      of embryos on day 3 with that of day 5, in correlation with their developmental 
      stage. SETTING: In vitro fertilization unit of a university-affiliated hospital. 
      PATIENT(S): Eighty-three aneuploid embryos. INTERVENTION(S): Fluorescence in situ 
      hybridization (FISH) reanalysis. MAIN OUTCOME MEASURE(S): Day 3 embryos 
      classified as mosaic or chromosomally abnormal by preimplantation genetic 
      screening (PGS) were reanalyzed on day 5. The results were evaluated in 
      correlation with the embryos' developmental stage. RESULT(S): Out of 83 day 3 
      aneuploid embryos, 15 (18.1%) were diagnosed with mosaicism. The FISH reanalysis 
      on day 5 demonstrated that 27 embryos (32.6%) were partly or entirely normal 
      disomic. Of these 83 aneuploid embryos, 8 (9.7%) underwent complete 
      self-correction. The PGS results demonstrated that 26.5% of the embryos were 
      trisomic, of which 41.0% underwent trisomic rescue by day 5. Self-correction was 
      in correlation with the embryo's developmental stage, i.e., 38.1% of aneuploid 
      embryos that developed to the blastocyst stage underwent self-correction compared 
      with only 12.5% of embryos that only cleaved after biopsy. CONCLUSION(S): Our 
      results demonstrate that self-correction of aneuploid and mosaic embryos occurs 
      probably more significantly during development toward the blastocyst stage than 
      in delayed embryos. In addition, trisomic embryos correct themselves more than 
      other aneuploidies. These findings suggest that PGS results must be interpreted 
      with caution.
FAU - Barbash-Hazan, Shiri
AU  - Barbash-Hazan S
AD  - Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv Sourasky 
      Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Frumkin, Tsvia
AU  - Frumkin T
AD  - Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv Sourasky 
      Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Malcov, Mira
AU  - Malcov M
AD  - Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv Sourasky 
      Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Yaron, Yuval
AU  - Yaron Y
AD  - Prenatal Diagnosis Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv 
      Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel 
      Aviv, Israel.
FAU - Cohen, Tania
AU  - Cohen T
AD  - Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv Sourasky 
      Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Azem, Foad
AU  - Azem F
AD  - Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv Sourasky 
      Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Amit, Ami
AU  - Amit A
AD  - Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv Sourasky 
      Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel.
FAU - Ben-Yosef, Dalit
AU  - Ben-Yosef D
AD  - Racine IVF Unit, Genetic Institute, Lis Maternity Hospital, Tel-Aviv Sourasky 
      Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 
      Israel. Electronic address: dalitb@tasmc.health.gov.il.
LA  - eng
PT  - Journal Article
DEP - 20080930
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - Biopsy
MH  - Blastocyst/pathology/*physiology
MH  - Cytogenetic Analysis/methods
MH  - Embryonic Development/*physiology
MH  - Female
MH  - Fertilization in Vitro/methods
MH  - Genetic Testing/methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
MH  - Prognosis
MH  - Prospective Studies
EDAT- 2008/10/03 09:00
MHDA- 2009/09/24 06:00
CRDT- 2008/10/03 09:00
PHST- 2008/05/19 00:00 [received]
PHST- 2008/07/10 00:00 [revised]
PHST- 2008/07/15 00:00 [accepted]
PHST- 2008/10/03 09:00 [pubmed]
PHST- 2009/09/24 06:00 [medline]
PHST- 2008/10/03 09:00 [entrez]
AID - S0015-0282(08)03284-6 [pii]
AID - 10.1016/j.fertnstert.2008.07.1761 [doi]
PST - ppublish
SO  - Fertil Steril. 2009 Sep;92(3):890-896. doi: 10.1016/j.fertnstert.2008.07.1761. 
      Epub 2008 Sep 30.