PMID- 18829428
OWN - NLM
STAT- MEDLINE
DCOM- 20081217
LR  - 20231105
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Print)
IS  - 0962-8436 (Linking)
VI  - 363
IP  - 1511
DP  - 2008 Dec 12
TI  - Anticipatory affect: neural correlates and consequences for choice.
PG  - 3771-86
LID - 10.1098/rstb.2008.0155 [doi]
AB  - 'Anticipatory affect' refers to emotional states that people experience while 
      anticipating significant outcomes. Historically, technical limitations have made 
      it difficult to determine whether anticipatory affect influences subsequent 
      choice. Recent advances in the spatio-temporal resolution of functional magnetic 
      resonance imaging, however, now allow researchers to visualize changes in neural 
      activity seconds before choice occurs. We review evidence that activation in 
      specific brain circuits changes during anticipation of monetary incentives, that 
      this activation correlates with affective experience and that activity in these 
      circuits may influence subsequent choice. Specifically, an activation likelihood 
      estimate meta-analysis of cued response studies indicates that nucleus accumbens 
      (NAcc) activation increases during gain anticipation relative to loss 
      anticipation, while anterior insula activation increases during both loss and 
      gain anticipation. Additionally, anticipatory NAcc activation correlates with 
      self-reported positive arousal, whereas anterior insula activation correlates 
      with both self-reported negative and positive arousal. Finally, NAcc activation 
      precedes the purchase of desirable products and choice of high-risk gambles, 
      whereas anterior insula activation precedes the rejection of overpriced products 
      and choice of low-risk gambles. Together, these findings support a neurally 
      plausible framework for understanding how anticipatory affect can influence 
      choice.
FAU - Knutson, Brian
AU  - Knutson B
AD  - Department of Psychology, Stanford University, Building 420, Jordan Hall, 
      Stanford, CA 94305, USA. knutson@psych.stanford.edu
FAU - Greer, Stephanie M
AU  - Greer SM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological 
      sciences
JID - 7503623
SB  - IM
MH  - Affect/*physiology
MH  - Brain/*physiology
MH  - Choice Behavior/*physiology
MH  - Humans
MH  - Neurons/physiology
PMC - PMC2607363
EDAT- 2008/10/03 09:00
MHDA- 2008/12/18 09:00
PMCR- 2009/12/12
CRDT- 2008/10/03 09:00
PHST- 2008/10/03 09:00 [pubmed]
PHST- 2008/12/18 09:00 [medline]
PHST- 2008/10/03 09:00 [entrez]
PHST- 2009/12/12 00:00 [pmc-release]
AID - 406873695606G704 [pii]
AID - rstb20080155 [pii]
AID - 10.1098/rstb.2008.0155 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2008 Dec 12;363(1511):3771-86. doi: 
      10.1098/rstb.2008.0155.