PMID- 18830194
OWN - NLM
STAT- MEDLINE
DCOM- 20081211
LR  - 20081002
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Linking)
VI  - 14
IP  - 10
DP  - 2008 Oct
TI  - Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene 
      variants on coronary artery disease in Turkish patients.
PG  - CR536-42
AB  - BACKGROUND: We investigated the association of matrix metalloproteinase-3 (MMP-3) 
      and paraoxonase 1 (PON1) 55/192 polymorphisms with coronary artery disease (CAD) 
      and the number of diseased vessels in patients with CAD. MATERIAL/METHODS: One 
      hundred thirty-nine CAD patients and 119 healthy control subjects were included 
      in the study. Genotypes for PON1 55/192 and MMP-3 5A/6A polymorphisms were 
      determined by restriction fragment length polymorphism. RESULTS: Although 
      distributions of the RR genotype of PON1 192 and the 5A5A genotype of MMP-3 were 
      more frequent in patients, frequencies of the QQ genotype of PON1 192, the MM 
      genotype of PON1 55, and the 6A6A genotype of MMP-3 were significantly lower in 
      patients compared with healthy control subjects. The combined genotypes of RR/LL 
      and/or 5A5A are increased the risk of CAD when compared with subjects who possess 
      neither the MMP-3 5A5A nor the PON1 RR/LL genotype. While the MMP-3 5A/6A genetic 
      variants were not associated with the number of diseased vessels, PON1 55/192 
      variants were associated with the number of diseased vessels. CONCLUSIONS: The 
      combined PON1 55/192 and MMP-3 5A/6A genetic variants are associated with CAD; 
      PON1 seems to be connected with the number of diseased vessels, and hypertension 
      and hyperlipidemia are related with PON1 192 and MMP-3 in CAD patients.
FAU - Ozkok, Elif
AU  - Ozkok E
AD  - Department of Neuroscience, The Institute of Experimental Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Aydin, Makbule
AU  - Aydin M
FAU - Babalik, Erhan
AU  - Babalik E
FAU - Ozbek, Zeynep
AU  - Ozbek Z
FAU - Ince, Nurhan
AU  - Ince N
FAU - Kara, Ihsan
AU  - Kara I
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Aryldialkylphosphatase/*genetics
MH  - Coronary Artery Disease/*genetics/pathology
MH  - Diabetes Mellitus/genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Hyperlipidemias/genetics
MH  - Hypertension/genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Myocardial Infarction/genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Turkey
EDAT- 2008/10/03 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/10/03 09:00
PHST- 2008/10/03 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/10/03 09:00 [entrez]
AID - 869417 [pii]
PST - ppublish
SO  - Med Sci Monit. 2008 Oct;14(10):CR536-42.