PMID- 18831944
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20170214
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 21
IP  - 3
DP  - 2008 Jul-Sep
TI  - Visceral leishmaniasis revealing chronic granulomatous disease in a child.
PG  - 739-43
AB  - We report the first description of visceral leishmaniasis (VL) infection as a 
      harbinger of chronic granulomatous disease (CGD) in a 3-year old child. Although 
      VL is not frequently suspected in CGD patients, our case emphasises the 
      importance of a complete evaluation of the immune system in children presenting 
      with VL in order to exclude underlying immunodeficiency states. As the prognosis 
      of CGD is poor, with high morbidity and mortality, establishing an early 
      diagnosis has important practical implications in the successful treatment of 
      these patients. Following the diagnosis, the patient received Human Leukocyte 
      Antigen (HLA) identical sibling bone marrow transplantation (BMT). The child is 
      now 2 years post-transplant and is in good general conditions with normal blood 
      counts, and evidence of full-donor chimerism in repeated fluorescence in situ 
      hybridization (FISH) studies.
FAU - Finocchi, A
AU  - Finocchi A
FAU - Palma, P
AU  - Palma P
FAU - Di Matteo, G
AU  - Di Matteo G
FAU - Chiriaco, M
AU  - Chiriaco M
FAU - Lancella, L
AU  - Lancella L
FAU - Simonetti, A
AU  - Simonetti A
FAU - Rana, I
AU  - Rana I
FAU - Livadiotti, S
AU  - Livadiotti S
FAU - Rossi, P
AU  - Rossi P
LA  - eng
PT  - Case Reports
PT  - Letter
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Reactive Oxygen Species)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Child, Preschool
MH  - Granulomatous Disease, Chronic/*complications
MH  - Humans
MH  - Interferon-gamma/physiology
MH  - Leishmaniasis, Visceral/*etiology
MH  - Reactive Oxygen Species/metabolism
EDAT- 2008/10/04 09:00
MHDA- 2008/11/19 09:00
CRDT- 2008/10/04 09:00
PHST- 2008/10/04 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/10/04 09:00 [entrez]
AID - 30 [pii]
AID - 10.1177/039463200802100330 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):739-43. doi: 
      10.1177/039463200802100330.