PMID- 18834246
OWN - NLM
STAT- MEDLINE
DCOM- 20090113
LR  - 20220410
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 79
IP  - 10
DP  - 2008 Oct
TI  - Bone remodeling biomarkers of periodontal disease in saliva.
PG  - 1913-9
LID - 10.1902/jop.2008.080070 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha), C-telopeptide pyridinoline 
      cross-links of type I collagen (ICTP), and receptor activator of nuclear 
      factor-kappa B ligand (RANKL) have been associated with bone remodeling and 
      periodontal tissue destruction. This study evaluated the level of these 
      biomarkers in saliva with respect to periodontal disease status. METHODS: Levels 
      of TNF-alpha in unstimulated whole saliva of 74 adults (35 subjects with moderate 
      to severe periodontal disease and 39 healthy controls) and salivary levels of 
      RANKL and ICTP of a subset of 21 subjects and 21 matched controls were examined 
      using enzyme immunosorbent assays in a case-control clinical study. RESULTS: 
      Salivary levels of TNF-alpha were detected in all subjects, whereas levels of 
      ICTP and RANKL were detected in only a minority of subjects. Mean salivary levels 
      of TNF-alpha were significantly higher in individuals with periodontal disease 
      (mean: 4.33 pg/ml) than in controls (mean: 2.03 pg/ml; P = 0.02), with a maximum 
      level (27.96 pg/ml) observed in periodontitis. Subjects with salivary TNF-alpha 
      levels above a threshold of 5.75 pg/ml (i.e., two standard deviations above the 
      mean of the controls) had significantly more sites with bleeding on probing, 
      probing depths >/=4 mm, and attachment loss > or =2 mm (P < or =0.01). 
      CONCLUSION: Salivary levels of TNF-alpha were elevated in patients who had 
      clinical indicators of periodontitis, suggesting that this biomarker may serve in 
      a panel of salivary biomarkers that could facilitate the screening, diagnosis, 
      and management of periodontal disease.
FAU - Frodge, Brandon D
AU  - Frodge BD
FAU - Ebersole, Jeffrey L
AU  - Ebersole JL
FAU - Kryscio, Richard J
AU  - Kryscio RJ
FAU - Thomas, Mark V
AU  - Thomas MV
FAU - Miller, Craig S
AU  - Miller CS
LA  - eng
GR  - M01-RR02602/RR/NCRR NIH HHS/United States
GR  - U01 DE017793/DE/NIDCR NIH HHS/United States
GR  - U01 DE15017/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
RN  - 0 (Peptides)
RN  - 0 (RANK Ligand)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (collagen type I trimeric cross-linked peptide)
SB  - IM
CIN - J Periodontol. 2009 Oct;80(10):1565-6; author reply 1566-7. PMID: 19792842
MH  - Adult
MH  - Alveolar Bone Loss/classification
MH  - Biomarkers/analysis
MH  - Bone Remodeling/*physiology
MH  - Case-Control Studies
MH  - Collagen Type I/*analysis
MH  - Female
MH  - Gingival Hemorrhage/classification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptides/*analysis
MH  - Periodontal Attachment Loss/classification
MH  - Periodontal Index
MH  - Periodontal Pocket/classification
MH  - Periodontitis/*classification
MH  - RANK Ligand/*analysis
MH  - Saliva/*chemistry
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - Young Adult
EDAT- 2008/10/07 09:00
MHDA- 2009/01/14 09:00
CRDT- 2008/10/07 09:00
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2009/01/14 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
AID - 10.1902/jop.2008.080070 [doi]
PST - ppublish
SO  - J Periodontol. 2008 Oct;79(10):1913-9. doi: 10.1902/jop.2008.080070.