PMID- 18834577
OWN - NLM
STAT- MEDLINE
DCOM- 20090108
LR  - 20220408
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 147
IP  - 1
DP  - 2009 Jan
TI  - Spectral-domain cirrus optical coherence tomography of choroidal striations seen 
      in the acute stage of Vogt-Koyanagi-Harada disease.
PG  - 148-153.e2
LID - 10.1016/j.ajo.2008.07.028 [doi]
AB  - PURPOSE: To describe changes in the retinal pigment epithelium (RPE) 
      corresponding to the choroidal striations in acute-stage Vogt-Koyanagi-Harada 
      (VKH) disease. DESIGN: Prospective, consecutive case series. METHODS: Four 
      patients (eight eyes) with acute-stage VKH disease were studied. All underwent 
      fundus fluorescein angiography (FFA), ultrasonography, and spectral-domain 
      optical coherence tomography (SD OCT). The main outcome measure was the 
      correlation of the findings seen on a 3-dimensional (3D) single-layer RPE map 
      constructed on SD OCT with the serous retinal detachment (RD) and choroidal 
      striations. RESULTS: The retina inner to external limiting membrane did not show 
      any structural alteration in any of the eyes. The 3D single-layer RPE map showed 
      undulations and bumps on the RPE surface in all the eyes. The troughs of the 
      undulations were noted to correspond to the choroidal striations seen as 
      hypofluorescent lines in the early phase of FFA. The bumps over the undulations 
      corresponded to the pinpoint hyperfluorescent dots on FFA, resulting in the 
      development of serous RDs over the troughs, thus obscuring the hypofluorescent 
      lines in the late phase of fluorescein angiograms. CONCLUSIONS: The troughs of 
      the RPE undulations were seen clinically as choroidal striations in the acute 
      uveitic stage of VKH disease.
FAU - Gupta, Vishali
AU  - Gupta V
AD  - Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Gupta, Amod
AU  - Gupta A
FAU - Gupta, Pawan
AU  - Gupta P
FAU - Sharma, Aman
AU  - Sharma A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20081002
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Glucocorticoids)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Acute Disease
MH  - Administration, Oral
MH  - Adult
MH  - Choroid Diseases/*diagnosis
MH  - Fluorescein Angiography
MH  - Glucocorticoids/administration & dosage
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Infusions, Intravenous
MH  - Methylprednisolone/administration & dosage
MH  - Pigment Epithelium of Eye/*pathology
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
MH  - Uveomeningoencephalitic Syndrome/*diagnosis/drug therapy
EDAT- 2008/10/07 09:00
MHDA- 2009/01/09 09:00
CRDT- 2008/10/07 09:00
PHST- 2008/04/09 00:00 [received]
PHST- 2008/07/18 00:00 [revised]
PHST- 2008/07/21 00:00 [accepted]
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2009/01/09 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
AID - S0002-9394(08)00580-1 [pii]
AID - 10.1016/j.ajo.2008.07.028 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2009 Jan;147(1):148-153.e2. doi: 10.1016/j.ajo.2008.07.028. Epub 
      2008 Oct 2.