PMID- 18834925
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20091119
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 446
IP  - 2-3
DP  - 2008 Dec 3
TI  - Lack of association between TNF-alpha polymorphisms and Alzheimer's disease in an 
      Italian cohort.
PG  - 139-42
LID - 10.1016/j.neulet.2008.09.044 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine that plays 
      an important role in the inflammatory process that can be observed in Alzheimer's 
      disease (AD) brain. Different functional promoter polymorphisms within genes 
      modulating inflammation have been demonstrated to elevate the AD risk; thus, we 
      studied five common variations within the promoter region of the TNF-alpha gene 
      in 609 subjects (253 AD patients and 356 controls). No positive associations were 
      found, confirming the greater part of previous studies. Moreover, we also 
      investigated the combined haplotypes of the five different polymorphisms without 
      finding a positive association. Thus, the present investigation does not support 
      the proposal that common nucleotide variations in the TNF-alpha gene can 
      influence the development of AD at least in Italian population.
FAU - Tedde, Andrea
AU  - Tedde A
AD  - Department of Neurological and Psychiatric Sciences, University of Florence, 
      Viale Pieraccini, 6-50139 Florence, Italy. tedde@unifi.it
FAU - Putignano, Anna Laura
AU  - Putignano AL
FAU - Nacmias, Benedetta
AU  - Nacmias B
FAU - Bagnoli, Silvia
AU  - Bagnoli S
FAU - Cellini, Elena
AU  - Cellini E
FAU - Sorbi, Sandro
AU  - Sorbi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Genetic Markers)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*genetics
MH  - Brain/*metabolism/physiopathology
MH  - Brain Chemistry/*genetics
MH  - Cohort Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genetic Variation/genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Mutation/genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Promoter Regions, Genetic/genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2008/10/07 09:00
MHDA- 2009/02/28 09:00
CRDT- 2008/10/07 09:00
PHST- 2008/08/27 00:00 [received]
PHST- 2008/09/11 00:00 [revised]
PHST- 2008/09/17 00:00 [accepted]
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
AID - S0304-3940(08)01304-9 [pii]
AID - 10.1016/j.neulet.2008.09.044 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Dec 3;446(2-3):139-42. doi: 10.1016/j.neulet.2008.09.044.