PMID- 18835263
OWN - NLM
STAT- MEDLINE
DCOM- 20090112
LR  - 20210816
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 41
IP  - 18
DP  - 2008 Dec
TI  - Age-related methylation in normal colon mucosa differs between the proximal and 
      distal colon in patients who underwent colonoscopy.
PG  - 1440-8
LID - 10.1016/j.clinbiochem.2008.08.089 [doi]
AB  - OBJECTIVES: To examine the difference in the methylation status in normal colon 
      mucosa between the proximal and distal colon, in relation to the correlation 
      between the methylation status of normal mucosa and characteristics of neoplasia. 
      DESIGN AND METHODS: Paired biopsy specimens of normal mucosa from the proximal 
      and distal colon of 82 patients who underwent colonoscopy were obtained. The 
      methylation status of the promoter region of estrogen receptor 1 (ESR1) and 
      myogenic differentiation 1 (MYOD1) was examined. RESULTS: Normal mucosa was more 
      highly methylated in the distal than in the proximal colon in both ESR1 and MYOD1 
      loci (p<0.0001 and p=0.0009, respectively). Advanced characteristics of polyps in 
      the distal colon were frequently observed in patients with lower methylation of 
      ESR1 in the distal colon normal mucosa. CONCLUSIONS: Methylation levels in normal 
      mucosa differ between the proximal and distal colon, and lower methylation of 
      ESR1 in the distal colon normal mucosa may correlate with advanced features of 
      neoplasia in the distal colon.
FAU - Horii, Joichiro
AU  - Horii J
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Hiraoka, Sakiko
AU  - Hiraoka S
FAU - Kato, Jun
AU  - Kato J
FAU - Harada, Keita
AU  - Harada K
FAU - Kuwaki, Kenji
AU  - Kuwaki K
FAU - Fujita, Hideyuki
AU  - Fujita H
FAU - Toyooka, Shinichi
AU  - Toyooka S
FAU - Yamamoto, Kazuhide
AU  - Yamamoto K
LA  - eng
PT  - Journal Article
DEP - 20080920
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (MyoD Protein)
RN  - 0 (MyoD1 myogenic differentiation protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Colon/*anatomy & histology/pathology
MH  - Colonic Polyps/metabolism/pathology
MH  - *Colonoscopy
MH  - Colorectal Neoplasms/metabolism/pathology
MH  - Estrogen Receptor alpha/genetics/metabolism
MH  - Female
MH  - Humans
MH  - Intestinal Mucosa/*metabolism/pathology
MH  - Male
MH  - Methylation
MH  - Middle Aged
MH  - MyoD Protein/genetics/metabolism
MH  - Promoter Regions, Genetic
MH  - Statistics as Topic
EDAT- 2008/10/07 09:00
MHDA- 2009/01/13 09:00
CRDT- 2008/10/07 09:00
PHST- 2008/03/24 00:00 [received]
PHST- 2008/08/12 00:00 [revised]
PHST- 2008/08/26 00:00 [accepted]
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2009/01/13 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
AID - S0009-9120(08)00382-2 [pii]
AID - 10.1016/j.clinbiochem.2008.08.089 [doi]
PST - ppublish
SO  - Clin Biochem. 2008 Dec;41(18):1440-8. doi: 10.1016/j.clinbiochem.2008.08.089. 
      Epub 2008 Sep 20.