PMID- 18835573
OWN - NLM
STAT- MEDLINE
DCOM- 20090311
LR  - 20151119
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 69
IP  - 12
DP  - 2008 Dec
TI  - Mycoplasma pneumoniae infection in a pediatric population: analysis of soluble 
      immune markers as risk factors for asthma.
PG  - 851-5
LID - 10.1016/j.humimm.2008.09.003 [doi]
AB  - Epidemiologic and clinical evidence suggests that respiratory tract infection 
      with Mycoplasma pneumoniae maybe implicated in the initiation and exacerbation of 
      asthma. This study examines the incidence and frequency of M. pneumoniae 
      infection in children and evaluates the serum cytokine profile and total 
      immunoglobulin E (IgE) levels in a subgroup of patients with clinical 
      presentation of either upper respiratory tract infections (URTI) or lower 
      respiratory tract infections (LRTI). A total of 6986 serum samples were tested 
      for specific IgM anti-M. pneumoniae, and a 4-year cyclical incidence of M. 
      pneumoniae infection was confirmed; however; the peak age of highest incidence in 
      the most recent epidemic fell to 3-4 years. A high incidence was also observed in 
      the 6-7-year age group. Children presenting with LRTI, when compared with those 
      patients presenting with URTI, had significantly higher serum levels of the 
      proinflammatory cytokines, interleukin (IL)-1alpha, IL-6, the T-helper (Th)2-type 
      cytokines, and IL-4 and IL-10. The Th1-type cytokines, IL-2 and IL-12, were 
      within the normal range, whereas interferon-gamma levels were slightly raised. 
      Total serum immunoglobulin E levels were significantly higher in the LRTI group 
      (p < 0.02). Our findings support the emerging evidence that respiratory tract 
      infection with Mycoplasma pneumoniae results in an increased proinflammatory and 
      Th2-type cytokine response that may precede the initiation and exacerbation of 
      asthma.
FAU - Hassan, Jaythoon
AU  - Hassan J
AD  - National Virus Reference Laboratory, School of Medicine and Medical Sciences, 
      University College Dublin, Dublin, Ireland. jaythoon.hassan@ucd.ie
FAU - Irwin, Fiona
AU  - Irwin F
FAU - Dooley, Seamus
AU  - Dooley S
FAU - Connell, Jeff
AU  - Connell J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081007
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/etiology/prevention & control
MH  - Biomarkers/*blood
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Ireland
MH  - Male
MH  - Mycoplasma pneumoniae/*immunology
MH  - Pneumonia, Mycoplasma/blood/complications/epidemiology/*immunology
MH  - Prevalence
MH  - Risk Factors
MH  - Th1 Cells/*immunology/metabolism
MH  - Th2 Cells/*immunology/metabolism
EDAT- 2008/10/07 09:00
MHDA- 2009/03/12 09:00
CRDT- 2008/10/07 09:00
PHST- 2008/06/10 00:00 [received]
PHST- 2008/08/26 00:00 [revised]
PHST- 2008/09/04 00:00 [accepted]
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2009/03/12 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
AID - S0198-8859(08)00473-4 [pii]
AID - 10.1016/j.humimm.2008.09.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2008 Dec;69(12):851-5. doi: 10.1016/j.humimm.2008.09.003. Epub 2008 
      Oct 7.