PMID- 18835699
OWN - NLM
STAT- MEDLINE
DCOM- 20090410
LR  - 20191210
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 19
IP  - 2
DP  - 2009 Feb
TI  - Dopamine D4 receptor antagonist L745,870 abolishes cognitive effects of 
      intracerebroventricular angiotensin IV and des-Phe(6)-Ang IV in rats.
PG  - 85-91
LID - 10.1016/j.euroneuro.2008.08.011 [doi]
AB  - In this study effect of L745,870, a selective D(4) dopamine (DA) receptor 
      blocker, on the pro-cognitive action of intracerebroventricularly (icv) injected 
      angiotensin IV (Ang IV) and des-Phe(6)-Ang IV was examined. Male Wistar rats 
      weighing 180-200 g were used. Both peptides given at the dose of 1 nmol 
      facilitated recall of a passive avoidance (PA) behaviour, improved object 
      recognition (OR) memory, decreased number of errors, increased number of 
      sequential correct entries and shortened time-to-goal in an eight-arm radial maze 
      (RM). In the auxiliary tests performed to control for the participation of 
      unspecific motor (open field, OF) and emotional ('plus' maze, PM) effects of our 
      treatment in the results of memory tests they had either no (OF) or negligible 
      (PM) effects. Intraperitoneal pretreatment of the animals with 1 mg/kg of 
      L745,870 abolished effects of both peptides on PA and OR and slightly diminished 
      those observed in the eight-arm RM.
FAU - Braszko, Jan J
AU  - Braszko JJ
AD  - Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 
      15A, 15-274 Bialystok, Poland. braszko@umwb.edu.pl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081005
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Pyridines)
RN  - 0 (Pyrroles)
RN  - 0 (angiotensin IV, des-Phe(6)-)
RN  - 11128-99-7 (Angiotensin II)
RN  - 137750-34-6 (Receptors, Dopamine D4)
RN  - 23025-68-5 (angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-)
SB  - IM
MH  - Angiotensin II/administration & dosage/*analogs & derivatives/antagonists & 
      inhibitors/pharmacology
MH  - Animals
MH  - Anxiety/psychology
MH  - Avoidance Learning/drug effects
MH  - Cognition/*drug effects
MH  - Data Interpretation, Statistical
MH  - Dopamine Antagonists/*pharmacology
MH  - Exploratory Behavior/drug effects
MH  - Form Perception/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mental Recall/drug effects
MH  - Motor Activity/drug effects
MH  - Pyridines/*pharmacology
MH  - Pyrroles/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Dopamine D4/*antagonists & inhibitors
MH  - Recognition, Psychology/drug effects
EDAT- 2008/10/07 09:00
MHDA- 2009/04/11 09:00
CRDT- 2008/10/07 09:00
PHST- 2008/07/07 00:00 [received]
PHST- 2008/08/04 00:00 [revised]
PHST- 2008/08/24 00:00 [accepted]
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2009/04/11 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
AID - S0924-977X(08)00235-6 [pii]
AID - 10.1016/j.euroneuro.2008.08.011 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2009 Feb;19(2):85-91. doi: 
      10.1016/j.euroneuro.2008.08.011. Epub 2008 Oct 5.