PMID- 18836452
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20231213
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 9
IP  - 11
DP  - 2008 Nov
TI  - CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress 
      acute graft-versus-host disease.
PG  - 1253-60
LID - 10.1038/ni.1658 [doi]
AB  - Dendritic cells (DCs) are 'professional' antigen-presenting cells that are key in 
      the regulation of immune responses. Here we characterize a unique subset of 
      tolerogenic DCs that expressed the chemokine receptor CCR9 and migrated to the 
      CCR9 ligand CCL25, a chemokine linked to the homing of T cells and DCs to the 
      gut. CCR9(+) DCs were of the plasmacytoid DC (pDC) lineage, had an immature 
      phenotype and rapidly downregulated CCR9 in response to maturation-inducing 
      pDC-restricted Toll-like receptor ligands. CCR9(+) pDCs were potent inducers of 
      regulatory T cell function and suppressed antigen-specific immune responses both 
      in vitro and in vivo, including inhibiting acute graft-versus-host disease 
      induced by allogeneic CD4(+) donor T cells in irradiated recipients. Our results 
      identify a highly immunosuppressive population of pDCs present in lymphoid 
      tissues.
FAU - Hadeiba, Husein
AU  - Hadeiba H
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, 
      California 94305, USA. hadeiba@stanford.edu
FAU - Sato, Tohru
AU  - Sato T
FAU - Habtezion, Aida
AU  - Habtezion A
FAU - Oderup, Cecilia
AU  - Oderup C
FAU - Pan, Junliang
AU  - Pan J
FAU - Butcher, Eugene C
AU  - Butcher EC
LA  - eng
GR  - R03 DK069395-01A1/DK/NIDDK NIH HHS/United States
GR  - T32 AI007290/AI/NIAID NIH HHS/United States
GR  - R37 GM037734/GM/NIGMS NIH HHS/United States
GR  - K08 DK069385/DK/NIDDK NIH HHS/United States
GR  - R03DK069395/DK/NIDDK NIH HHS/United States
GR  - AI07290/AI/NIAID NIH HHS/United States
GR  - K08DK069385/DK/NIDDK NIH HHS/United States
GR  - K08 DK069385-01A1/DK/NIDDK NIH HHS/United States
GR  - R01 DK084647/DK/NIDDK NIH HHS/United States
GR  - R37 GM037734-13/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20081005
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Biomarkers)
RN  - 0 (Ccl25 protein, mouse)
RN  - 0 (Chemokines, CC)
RN  - 0 (Ligands)
RN  - 0 (Receptors, CCR10)
RN  - 0 (Toll-Like Receptors)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
RN  - EC 3.1.3.48 (Ptprc protein, mouse)
SB  - IM
CIN - Am J Transplant. 2012 Nov;12(11):2867. PMID: 23107267
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Differentiation
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Chemokines, CC/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Down-Regulation
MH  - Graft vs Host Disease/*immunology
MH  - Intestines/immunology
MH  - Leukocyte Common Antigens/metabolism
MH  - Ligands
MH  - Mice
MH  - Mice, Congenic
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Receptors, CCR10/*immunology/metabolism
MH  - *Self Tolerance
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Toll-Like Receptors/metabolism
MH  - *Transplantation Tolerance
MH  - Chemokine Receptor D6
PMC - PMC2901237
MID - NIHMS211511
EDAT- 2008/10/07 09:00
MHDA- 2008/11/19 09:00
PMCR- 2010/07/09
CRDT- 2008/10/07 09:00
PHST- 2008/03/10 00:00 [received]
PHST- 2008/08/25 00:00 [accepted]
PHST- 2008/10/07 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/10/07 09:00 [entrez]
PHST- 2010/07/09 00:00 [pmc-release]
AID - ni.1658 [pii]
AID - 10.1038/ni.1658 [doi]
PST - ppublish
SO  - Nat Immunol. 2008 Nov;9(11):1253-60. doi: 10.1038/ni.1658. Epub 2008 Oct 5.