PMID- 18840195
OWN - NLM
STAT- MEDLINE
DCOM- 20090108
LR  - 20081008
IS  - 1341-8076 (Print)
IS  - 1341-8076 (Linking)
VI  - 34
IP  - 4 Pt 2
DP  - 2008 Aug
TI  - Endometrial carcinoma in a patient having 45,X Turner syndrome with gonadal 
      mosaicism.
PG  - 745-8
LID - 10.1111/j.1447-0756.2008.00918.x [doi]
AB  - Only three cases of endometrial carcinoma in women with possibly pure 45,X Turner 
      syndrome without previous unopposed estrogen therapy have been reported. A 
      46-year-old single nulligravid woman with Turner syndrome phenotype, spontaneous 
      menstruation, and well-differentiated adenocarcinoma of the endometrium was 
      diagnosed as having the 45,X karyotype from peripheral blood, skin, buccal cells, 
      and endometrium, which was confirmed using fluorescence in situ hybridization 
      (FISH). Analysis of the ovarian tissue using FISH confirmed 45,X/46,XX mosaicism. 
      Gonadal mosaicism may help to interpret spontaneous menstruation and endometrial 
      carcinoma in possibly pure 45,X Turner syndrome. We conclude that a molecular 
      analysis of lymphocytes and various tissues is necessary for detecting low-level 
      mosaicism in apparently homogeneous 45,X women.
FAU - Park, Ji Kwon
AU  - Park JK
AD  - Department of Obstetrics and Gynecology, Gyeongsang National University, JinJu, 
      Korea.
FAU - Lee, Jae Ik
AU  - Lee JI
FAU - Kim, Dong Chul
AU  - Kim DC
FAU - Jo, Hyun Cheol
AU  - Jo HC
FAU - Shin, Jeong Kyu
AU  - Shin JK
FAU - Lee, Soon Ae
AU  - Lee SA
FAU - Lee, Jong Hak
AU  - Lee JH
FAU - Paik, Won Young
AU  - Paik WY
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
SB  - IM
MH  - Adenocarcinoma/*complications/pathology
MH  - Endometrial Neoplasms/*complications/pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Middle Aged
MH  - *Mosaicism
MH  - Ovary/*pathology
MH  - Turner Syndrome/*complications/pathology
MH  - Uterus/*pathology
EDAT- 2008/10/09 09:00
MHDA- 2009/01/09 09:00
CRDT- 2008/10/09 09:00
PHST- 2008/10/09 09:00 [pubmed]
PHST- 2009/01/09 09:00 [medline]
PHST- 2008/10/09 09:00 [entrez]
AID - JOG918 [pii]
AID - 10.1111/j.1447-0756.2008.00918.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2008 Aug;34(4 Pt 2):745-8. doi: 
      10.1111/j.1447-0756.2008.00918.x.