PMID- 18840465
OWN - NLM
STAT- MEDLINE
DCOM- 20090326
LR  - 20131121
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 29
IP  - 6
DP  - 2008 Nov
TI  - Effects of early gestational all-trans retinoic acid treatment on motor skills: a 
      longitudinal study in the offspring of Sprague-Dawley rats.
PG  - 1107-13
LID - 10.1016/j.neuro.2008.09.003 [doi]
AB  - The purpose of the present study was to investigate the behavioral outcomes of 
      all-trans retinoic acid (RA) treatment in the period spanning gestational day 
      (GD) 8-10. A sublethal dose (2.5mg/kg b.w.) compatible with high neonatal 
      survival, sufficient to supply male offspring for later behavioral testing, was 
      used. Indeed, the mortality rate at birth was 7.8%. Reproduction parameters (body 
      weight gain of dams during gestation, number of dams giving birth, pregnancy 
      length, litter size at birth), offspring body weight gain and the development of 
      their somatic characteristics (ear unfolding, auditory conduit opening, eyes 
      opening, hair growth) were not altered by RA. Instead, the onset of righting 
      reflex and negative geotaxis were delayed by 2 days, suggesting vestibular 
      involvement and abnormal functioning of the cerebellum. Then, the performance of 
      RA-treated rats on open field and rotarod/accelerod tasks was assessed from 
      postnatal day (PND) 21 to 90. Similar to the previously investigated GD 11-13 RA 
      treatment, the GD 8-10 RA treatment impaired the open field activity and 
      rotarod/accelerod performance in young adult rats, thus suggesting a 
      task-specific rather than a stage-specific effect of low-dose retinoids during 
      brain development. The delayed appearance of these outcomes underlines the 
      relevance of longitudinal studies to sort out specific RA-targeted 
      neurochemical-behavioral pathways that could be labelled as having no phenotype 
      based on standard examination at birth.
FAU - Coluccia, Addolorata
AU  - Coluccia A
AD  - Department of Pharmacology and Human Physiology, School of Medicine, University 
      of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
FAU - Borracci, Pietro
AU  - Borracci P
FAU - Belfiore, Domenico
AU  - Belfiore D
FAU - Renna, Giuseppe
AU  - Renna G
FAU - Giustino, Arcangela
AU  - Giustino A
FAU - Carratu, Maria Rosaria
AU  - Carratu MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080918
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Antineoplastic Agents)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Antineoplastic Agents/*pharmacology
MH  - Body Weight/drug effects
MH  - Female
MH  - Hand Strength
MH  - Male
MH  - Motor Activity/drug effects
MH  - Motor Skills/*drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex/drug effects
MH  - Reproduction/drug effects
MH  - Rotarod Performance Test
MH  - Statistics, Nonparametric
MH  - Tretinoin/*pharmacology
EDAT- 2008/10/09 09:00
MHDA- 2009/03/27 09:00
CRDT- 2008/10/09 09:00
PHST- 2008/07/10 00:00 [received]
PHST- 2008/08/28 00:00 [revised]
PHST- 2008/09/04 00:00 [accepted]
PHST- 2008/10/09 09:00 [pubmed]
PHST- 2009/03/27 09:00 [medline]
PHST- 2008/10/09 09:00 [entrez]
AID - S0161-813X(08)00179-4 [pii]
AID - 10.1016/j.neuro.2008.09.003 [doi]
PST - ppublish
SO  - Neurotoxicology. 2008 Nov;29(6):1107-13. doi: 10.1016/j.neuro.2008.09.003. Epub 
      2008 Sep 18.