PMID- 18841010
OWN - NLM
STAT- MEDLINE
DCOM- 20090108
LR  - 20081020
IS  - 1421-9824 (Electronic)
IS  - 1420-8008 (Linking)
VI  - 26
IP  - 3
DP  - 2008
TI  - Investigation of the role of the dopamine transporter in susceptibility to 
      behavioural and psychological symptoms of patients with probable Alzheimer's 
      disease.
PG  - 257-60
LID - 10.1159/000160958 [doi]
AB  - BACKGROUND/AIMS: Alzheimer's disease patients commonly suffer from behavioural 
      and psychological symptoms of dementia (BPSD); a genetic component to the 
      development of BPSD has been demonstrated. Genetic risk factors for other 
      psychiatric disorders have been implicated in BPSD; however, this is the first 
      known investigation of the dopamine transporter (DAT1) gene in BPSD. METHODS: Our 
      large cohort of 395 patients with probable Alzheimer's disease was dichotomised 
      into whether they had ever suffered from a given symptom over the study period or 
      not, based on longitudinal data using the BPSD (Neuropsychiatric Inventory). 
      These measures were related to the DAT1 3'-untranslated region (UTR) variable 
      number tandem repeat (VNTR) polymorphism. RESULTS: Potential associations were 
      revealed between the 9-repeat allele and presence of irritability and between the 
      10-repeat allele and aberrant motor behaviour (AMB); however, these do not remain 
      significant after correction for multiple testing. No associations were observed 
      with delusions, hallucinations, depression, agitation/aggression or elation. 
      CONCLUSION: Our data suggest that the DAT1 3'-UTR VNTR could play a role in 
      susceptibility to irritability and AMB. The findings presented here require 
      replication in large well-characterised cohorts.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Pritchard, Antonia L
AU  - Pritchard AL
AD  - Molecular Psychiatry Group, Population Studies and Human Genetics, Queensland 
      Institute of Medical Research, Brisbane, Qld., Australia. 
      Antonia.Pritchard@qimr.edu.au
FAU - Pritchard, Colin W
AU  - Pritchard CW
FAU - Bentham, Peter
AU  - Bentham P
FAU - Lendon, Corinne L
AU  - Lendon CL
LA  - eng
PT  - Journal Article
DEP - 20081008
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Aged
MH  - Aged, 80 and over
MH  - Aggression/physiology
MH  - Alzheimer Disease/epidemiology/*genetics/*psychology
MH  - Cohort Studies
MH  - Depression/genetics
MH  - Dopamine Plasma Membrane Transport Proteins/*genetics/metabolism
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genotype
MH  - Humans
MH  - Irritable Mood/physiology
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Disorders/epidemiology/*genetics/*psychology
MH  - Phenotype
MH  - Risk Factors
MH  - Tandem Repeat Sequences
EDAT- 2008/10/09 09:00
MHDA- 2009/01/09 09:00
CRDT- 2008/10/09 09:00
PHST- 2008/05/16 00:00 [accepted]
PHST- 2008/10/09 09:00 [pubmed]
PHST- 2009/01/09 09:00 [medline]
PHST- 2008/10/09 09:00 [entrez]
AID - 000160958 [pii]
AID - 10.1159/000160958 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2008;26(3):257-60. doi: 10.1159/000160958. Epub 2008 
      Oct 8.