PMID- 1884102
OWN - NLM
STAT- MEDLINE
DCOM- 19911007
LR  - 20190510
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 103
IP  - 2
DP  - 1991 Jun
TI  - IgE-dependent activation of alveolar macrophages augments neurally mediated 
      contraction of small airways.
PG  - 1458-62
AB  - 1. We studied the effect of immunologically activated pulmonary alveolar 
      macrophages (PAM) on functions of canine bronchiolar smooth muscle under 
      isometric conditions in vitro. 2. PAM, stimulated with monoclonal 
      anti-dinitrophenyl (DNP) IgE antibody and DNP-human serum albumin (DNP-HSA), 
      augmented the contractile responses of bronchioles to electrical field 
      stimulation, whereas PAM treated with IgE antibody alone had no effect. 3. In 
      contrast, the contractile responses to exogenously administered acetylcholine 
      were not influenced by immunologically activated PAM. 4. The PAM-induced increase 
      in the contractile responses to field stimulation was inhibited by pretreatment 
      of PAM with indomethacin and by addition of the thromboxane A2 (TxA2) receptor 
      antagonist SQ 29548. 5. The release of TxA2 from PAM was increased by anti-DNP 
      IgE and DNP-HSA, an effect that was prevented by indomethacin. 6. These results 
      suggest that PAM may play a role in the development of antigen-induced 
      hyperreactivity of small airways through an IgE-dependent release of TxA2 which 
      potentiates prejunctionally the parasympathetic component of bronchiolar smooth 
      muscle tone.
FAU - Tamaoki, J
AU  - Tamaoki J
AD  - First Department of Medicine, Tokyo Women's Medical College, Japan.
FAU - Sakai, N
AU  - Sakai N
FAU - Kanemura, T
AU  - Kanemura T
FAU - Yamawaki, I
AU  - Yamawaki I
FAU - Takizawa, T
AU  - Takizawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Dinitrophenols)
RN  - 0 (Eicosanoids)
RN  - 0 (Serum Albumin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7BO8G1BYQU (Masoprocol)
RN  - N9YNS0M02X (Acetylcholine)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Animals
MH  - Bronchi/drug effects/innervation
MH  - Dinitrophenols/immunology
MH  - Dogs
MH  - Eicosanoids/metabolism
MH  - Electric Stimulation
MH  - Female
MH  - Immunoglobulin E/*physiology
MH  - In Vitro Techniques
MH  - Indomethacin/pharmacology
MH  - Macrophage Activation/*drug effects
MH  - Macrophages/drug effects/enzymology
MH  - Male
MH  - Masoprocol/pharmacology
MH  - Muscle Contraction/drug effects
MH  - Pulmonary Alveoli/cytology
MH  - *Respiratory Physiological Phenomena
MH  - Respiratory System/innervation
MH  - Serum Albumin/immunology
PMC - PMC1908374
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
PMCR- 1992/06/01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
PHST- 1992/06/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1991.tb09811.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1991 Jun;103(2):1458-62. doi: 10.1111/j.1476-5381.1991.tb09811.x.